Recent neuropsychological evidence suggested a role for the right prefrontal cortex in temporal orienting of attention guided by symbolic cues, and the left prefrontal cortex in preparation guided by rhythms. We tested this hypothesis by comparing the effects of 1-Hz repetitive transcranial magnetic stimulation (TMS) over prefrontal regions on the performances of two temporal preparation tasks,...

Abstract The subjective presence experience in virtual reality (VR) is associated with distinct brain activation patterns. Particularly, the dorsolateral prefrontal cortex (DLPFC) seems to play a central role. We investigated effects of electric stimulation (transcranial direct current, tDCS) on as well activity and connectivity. Thirty-eight participants received either anodal ( N = 18) or cat...

Abstract Background Headache is the most common pain disorder , affecting around 66% of global population. This study aimed to investigate efficacy high-frequency repetitive transcranial magnetic stimulation (rTMS) in treating patients with primary chronic daily headaches (chronic tension-type headache and migraine). Methods Twenty-seven participated study, divided into 2 groups: a group (16 pa...

Research indicates that dorsolateral prefrontal cortex (DLPFC) is important for pursuing goals, and areas of DLPFC are differentially involved in approach and avoidance motivation. Given the complexity of the processes involved in goal pursuit, DLPFC is likely part of a network that includes orbitofrontal cortex (OFC), cingulate, amygdala, and basal ganglia. This hypothesis was tested with rega...

During the last decade, repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has become established as a treatment for various mental diseases. The rational of prefrontal stimulation has been adapted from the mode of action known from rTMS using motor-evoked potentials though little is known about the precise effect of rTMS at prefrontal sites. The objective of the curre...

UNLABELLED Maintenance of context is necessary for execution of appropriate responses to diverse environmental stimuli. The dorsolateral prefrontal cortex (DLPFC) plays a pivotal role in executive function, including working memory and representation of abstract rules. DLPFC activity is modulated by the ascending cholinergic system through nicotinic and muscarinic receptors. Although muscarinic...

Although cognitive neuroscience has made remarkable progress in understanding the involvement of the prefrontal cortex in executive control functions for human intelligence, the necessity of the dorsolateral prefrontal cortex (dlPFC) for key competencies of general intelligence and executive function remains to be well established. Here we studied human brain lesion patients with dlPFC lesions ...

Emotions are frequently characterized by distinct dimensions such as valence, intensity, and recognition. However, the exact neural representation of these dimensions in different prefrontal cortical regions remains unclear. One of the problems in revealing prefrontal cortical representation is that the very same regions are also involved in cognitive functions associated with emotion processin...

Understanding the neural mechanisms of control regulation requires delineating specific functional roles for individual neural structures, and consequently their functional relationships. Higher-order control over behavior has traditionally been seen as the function of the prefrontal cortex (PFC). Models of various aspects of control, including top-down processing, decision making, and performa...

Transcranial static magnetic field stimulation (tSMS) can modulate human cortical excitability and behavior. To better understand the neuromodulatory effect of tSMS, this study investigates whether tSMS applied over left dorsolateral prefrontal cortex (DLPFC) modulates working memory (WM) performance its associated event-related potentials (ERPs). Thirteen healthy participants received or sham ...