BACKGROUND No selection criteria for helical tomotherapy (HT) based stereotactic ablative radiotherapy (SABR) to treat early stage non-small cell lung cancer (NSCLC) or solitary lung metastases has been established. In this study, we investigate the dosimetric selection criteria for HT based SABR delivering 70 Gy in 10 fractions to avoid severe toxicity in the treatment of centrally located les...

PURPOSE To develop an automated beam placement technique for whole breast radiotherapy using tangential beams. We seek to find optimal parameters for tangential beams to cover the whole ipsilateral breast (WB) and minimize the dose to the organs at risk (OARs). METHODS A support vector machine (SVM) based method is proposed to determine the optimal posterior plane of the tangential beams. Rel...

As regards, the selection of appropriate energy in radiotherapy tumors that are placed in non-homogen areas is important, so the aim of the present study is evaluating the effect of 6 and 15MV photon beam energies on dose distribution in 3D-CRT for lower esophageal and rectal cancers. 12 patients with lower esophageal cancer and 12 patients with rectal cancer respectively, with the prescription...

Background: To compare the dosimetric coverage of the planning target volume (PTV) and the dose delivered to the main Organs at Risk (OARs) in 5 and 7-field techniques of Intensity Modulated Radiation Therapy (IMRT) in patients with local prostate cancer. Materials and Methods: Twelve patients with local prostate cancer underwent 5 and 7-field IMRT planning. The delivery of IMRT was carried out...

PURPOSE/OBJECTIVE To develop a method to predict feasible organ-at-risk (OAR) and tumour dose levels of non-small cell lung cancer (NSCLC) patients prior to the start of treatment planning. MATERIALS/METHODS Included were NSCLC patients treated with volumetric modulated arc therapy according to an institutional isotoxic dose-escalation protocol. A training cohort (N=50) was used to calculate ...

Abstract Purpose: Head and neck (HN) radiotherapy (RT) is complex, involving multiple target organ at risk (OAR) structures delineated by the radiation oncologist. Site-agnostic peer review after RT plan completion often inadequate for thorough of these structures. In-depth contours critical to maintain high-quality optimal patient outcomes. Materials Methods: In August 2020, HN Quality Assuran...

PURPOSE Robust optimization leads to IMPT plans that are more robust than and superior in optimality compared to PTV-based optimized plans. Robust optimization incorporates setup and range uncertainties, which implicitly adds margins to targets and organs-at-risk (OARs); whereas PTV-based optimization only considers setup uncertainties and adds margins only to targets in practice. The purpose o...

The aim of this work is to develop and investigate an inverse treatment planning process (TPP) for mixed beam radiotherapy (MBRT) capable of performing simultaneous optimization of photon and electron apertures. A simulated annealing based direct aperture optimization (DAO) is implemented to perform simultaneous optimization of photon and electron apertures, both shaped with the photon multilea...

BACKGROUND To investigate the feasibility and dosimetric improvements of a novel technique to temporarily displace critical structures in the pelvis and abdomen from tumor during high-dose radiotherapy. METHODS Between 2010 and 2012, 11 patients received high-dose image-guided intensity-modulated radiotherapy with temporary organ displacement (TOD) at our institution. In all cases, imaging re...