The objective of this study was to assess pregnancy outcome in women with a history of refractory antiphospholipid antibody-associated pregnancy loss(es) who were treated with early low-dose prednisolone in addition to aspirin and heparin. Eighteen women with antiphospholipid antibodies who had refractory pregnancy loss(es) were given prednisolone (10 mg) from the time of their positive pregnan...

The Giant Cell Arteritis Actemra (GiACTA) study, the largest randomised trial for this disease to date, involved 251 patients and describes the benefits of tocilizumab, an interleukin-6 inhibitor.1 Patients were randomised to one of 4 groups, in a ratio of 2:1:1:1, to receive: subcutaneous tocilizumab 162 mg weekly (100 patients); or every 2 weeks (50 patients); or placebo (one arm of 50 patien...

1. Derivatization of nonsteroidal anti-inflammatory drugs, such that they release nitric oxide (NO) in small amounts, has been shown to significantly increase their anti-inflammatory activity and analgesic potency. In this study, we compared the anti-inflammatory potency of prednisolone to a nitric oxide-releasing derivative of prednisolone (NCX-1015). 2. Carrageenan-induced inflammation of an ...

The effect of prednisolone on the elimination kinetics of theophylline was studied in a group of nine patients with chronic airflow obstruction. Volume of distribution, plasma half life, and clearance after a single intravenous dose of aminophylline (5.6 mg/kg) were unchanged by prednisolone treatment (20 mg daily for three weeks). The metabolism of an intravenous bolus of theophylline is not i...

PURPOSE To compare the dose uniformity of difluprednate ophthalmic emulsion 0.05% (Durezol(®)) with both branded and generic prednisolone acetate ophthalmic suspension 1% under different simulated patient usage conditions. METHODS Drug concentrations of difluprednate emulsion, branded prednisolone acetate suspension (Pred Forte(®)) and generic prednisolone acetate suspension following three s...

BACKGROUND HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression. METHODS In an observational study, we determined immune activation in HIV patients receiving low-dose (5 mg/day) prednisolone with or without hi...

A 72 year-old man. He was diagnosed with rheumatoid arthritis in 2002. In January 2005 he noted productive cough and fever; he was diagnosed as eosinophilic pneumonia (EP). We discontinued administration of bucillamine and methotrexate and started to treat with oral prednisolone 30 mg daily. To rule out drug-induced EP, prednisolone was tapered by 10 mg per week. Consolidation occurred in the r...

BACKGROUND Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after ...