Abstract The high cost of maintenance, repair and retrofitting concrete infrastructure to keep these structures durable serviceable is not sustainable, so the design process needs consider all aspects deterioration mechanism/s that can potentially occur in a structure. ideal solution should contribute sustainability by enhancing durability elements supporting circular economy. We studied delaye...

Introduction: Many study shown the effectiveness dose enhancement with gold nanoparticles (GNPs), especially with low-energy x-rays. Recently, proton beam radiation therapy (PBRT) has attention as a treatment for tumors. The advantage in PBRT, which releases high dose at the controllable Bragg peak position that localized for Au target and the released dose increased in depth....

Background The cytotoxic effects of microtubule-targeting agents (MTAs) are often attributed to targeted effects on mitotic cells. In clinical practice, MTAs are combined with DNA-damaging agents such as ionizing radiation (IR) with the rationale that mitotic cells are highly sensitive to DNA damage. In contrast, recent studies suggest that MTAs synergize with IR by interfering with the traffic...

Background: External beam radiation therapy is often administered to patients implanted with silicone gel breast prosthesis. The aim of this study was to investigate the influence of silicone gel breast prosthesis on photon dose distributions. In the event of recurrence, the oncologist may be forced to irradiate through the prosthetic device. To quantify the dose enhancement or reduction below ...

Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on human genome, either directly or indirectly, can change expression and structure genes. One micronutrients associated with periodontitis vitamin D. Vitamin D has an important role in bone calcium metabolism regulates serum phosphate concentrations at normal limits. Purpose: To discus...

The metazoan liver exhibits a remarkable capacity to regenerate lost liver mass without leaving a scar following partial hepatectomy (PH). Whilst previous studies have identified components of several different signaling pathways that are essential for activation of hepatocyte proliferation during liver regeneration, the mechanisms that enable such regeneration to occur without accompanying sca...

We propose Deep Estimators of Features (DEFs), a learning-based framework for predicting sharp geometric features in sampled 3D shapes. Differently from existing data-driven methods, which reduce this problem to feature classification, we regress scalar field representing the distance point samples closest line on local patches. Our approach is first that scales massive clouds by fusing distanc...

BACKGROUND Locoregional recurrence is a major problem in esophageal cancer patients treated with definitive concomitant chemoradiotherapy. Approximately half of the patients fail locoregionally. We analyzed the impact of enlarged radiation field size and higher radiation dose incorporated to chemoradiotherapy on oncologic outcome. METHODS Seventy-four consecutive patients with histologically ...

The Src homology 3 (SH3) motif is found in numerous signal transduction proteins involved in cellular growth and differentiation. We have purified and cloned a novel protein, DEF-1 (differentiation-enhancing factor), from bovine brain by using a Src SH3 affinity column. Ectopic expression of DEF-1 in fibroblasts resulted in the differentiation of a significant fraction of the culture into adipo...

background: gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions. objective: the ability of a new formulation of magic-f polymer gel was assessed by experimental measurement and monte carlo (mc) method for studying the effect of gold nanoparticles (gnps) in prostate dose distributions under the internal ir-192 and external 18mv radioth...