-Cis-dichlorobis(cyclopentylamine)platinum II (DBCP) belongs to the group of platinum complexes which have recently been reported to have anti-tumour activity. Its cytotoxic activity in CHO cells is not cell-age-dependent, but enhancement of the effect of ionizing radiation is both dose-and cell cycle phase-dependent. In asynchronous cell populations DBCP acts as a dose-modifying factor for ion...

PURPOSE Bombarding high-Z material with x-ray radiation releases Auger electrons and Coster-Kronig electrons, along with deeper penetrating fluorescent x-rays and photoelectrons. The Auger and Coster-Kronig electron penetration distance is on the order of nanometers to micrometers in water or tissue, creating a large dose enhancement accompanied by a RBE greater than 1 at the cellular level. Th...

Introduction Magnetic fields are capable of altering the trajectory of electron beams andcan be used in radiation therapy.Theaim of this study was to produce regions with dose enhancement and reduction in the medium. Materials and Methods The NdFeB permanent magnets were arranged on the electron applicator in several configurations. Then, after the passage of the electron beams (9 and 15 MeV Va...

A digital phantom was created from a CT scan of patient’s head and employed together with GATE 8.2 Monte Carlo modeling linear accelerator nominal 6 MV energy to simulate an irradiation geometry for typical tumor volume centrally within the brain region. Although simplistic in arrangement, this setup considered appropriate demonstrate dose enhancements that may be expected megavoltage external ...

The radiosensitizing potential of gemcitabine (2',2'-difluoro-2'-deoxycytidine) was studied in combination with pulsed low dose-rate irradiation. The experiments were carried out with a human lung carcinoma cell line SW1573. These were irradiated at pulsed low dose rate (p-LDR); the average dose rate was 1 Gy/h. In the experiments with gemcitabine, this drug was applied for 24 h at a concentrat...

The purpose of this study was to analyse the effects of the type, concentration, and nanoparticle diameter of dose enhancement materials on the dose enhancement of low- and high-energy megavoltage (MV) X-rays acquired from a medical linear accelerator using Monte Carlo simulation. Monte Carlo simulation was performed with the Monte Carlo N-Particle Transport (MCNPX) code, using the energy spect...

the thermo-hydraulic behavior of the air flow over a two dimensional ribbed channel wasnumerically investigated in various rib-width ratio configurations (b/h=0.5-1.75) atdifferent reynolds numbers, ranging from 6000 to 18000. the capability of differentturbulence models, including standard k-ε, rng k-ε, standard k-ω, and sst k-ω, inpredicting the heat transfer rate was compared with the experi...