selective serotonin reuptake inhibitors (ssris) are reported to be associated with increased bleeding tendency. while findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue ssris as harmful medications. we report two instances of dose-dependent relations between sertraline and bleeding tendency. bleeding diathesis was a...

Echinocandins are indicated as first-line treatment for invasive candidiasis in moderate to severe illness. As sepsis is the main cause of acute kidney injury, the combination of echinocandin treatment and continuous renal replacement therapy (CRRT) is common. Optimizing antibiotic dosage in critically ill patients receiving CRRT is challenging. The pharmacokinetics of echinocandins have been s...

Long-distance travel across multiple time zones presents unique challenges for patients taking insulin, requiring adjustments in both timing and dosage of basal insulin when several times zones (≥5) are traversed. Travel across the International Date Line adds to the confusion, as existing resources and dosing calculators often do not account for the date change. We review recommendations from ...

We evaluated the usefulness of therapeutic drug monitoring (TDM) for gentamicin and the use of a two-point peak and trough pair concentration method to adjust its dose. Of the 194 patients included, initial concentrations were appropriate in only sixty nine. In the seventy one cases of dosage adjustments using this method, those attaining therapeutic levels increased overall from 38% to 67%. It...

Chronic renal disease is frequent in the general population. In the case of epidemia or pandemia of avian influenza A (H5N1), the two neuraminidase inhibitors, oseltamivir and zanamivir will therefore be used in patients with renal impairment. Although zanamivir does not necessitate any adjustment of its dosage in patients with renal failure, because it is not absorbed after oral inhalation, os...

Copyright: © 2016 Polo F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the clinical practice, therapeutic drug monitoring (TDM) concerns the analytical determination of pharmaceutical drug concent...

153. Kaatz S, Elston-Lafata J, Gooldy S. Anticoagulation therapy home and office evaluation (AT HOME) study. Thromb Haemost. 2001; 86(suppl):P779. Abstract. 154. Wilson R, James AH. Computer assisted management of warfarin treatment. Br Med J. 1984;289:422–424. 155. White RH, Mungall D. Outpatient management of warfarin therapy: comparison of computer-predicted dosage adjustment to skilled prof...

INTRODUCTION Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS RA patients routinely treated with infliximab were included in an observational open...

Recent studies have reported that the pharmacokinetics of high-dose busulfan in bone marrow transplantation (BMT) are age-dependent: with the usual dosage of 16 mg/kg over 4 days, systemic exposure is two to four times lower in children than in adults. Data suggested that the dose of busulfan should rather be calculated on the basis of the body surface area (BSA). We measured plasma pharmacokin...