To further define the sensory projections to the circle of Willis, we measured concentrations of immunoreactive substance P in pial arteries of cats following either bilateral removal of the C1-3 dorsal root ganglia (six cats) or bilateral removal of the trigeminal ganglia (three cats). Removal of the dorsal root ganglia decreased concentrations of the tachykinin substance P in the vertebral ar...

Most studies on rabies virus pathogenesis in animal models have employed fixed rabies viruses, and the results of those employing street rabies viruses have been inconsistent. Therefore, to clarify the pathogenesis of street rabies virus (1088 strain) in mice, 106 focus forming units were inoculated into the right hindlimb of ddY mice (6 weeks, female). At 3 days postinoculation (DPI), mild inf...

Sir, In their elegant study, Üçeyler et al. (2013) provide objective evidence of small fibre neuropathy in patients with fibromyalgia. They conclude that fibromyalgia may be a neuropathic pain syndrome (Üçeyler et al., 2013). Small fibre neuropathy is a disorder of the peripheral nerves resulting in sensory changes and sympathetic dysfunction. For years, we have proposed that fibromyalgia is a ...

Immunocytochemical analysis of the distribution of dynorphin B terminals in the sacral spinal cord of the cat revealed a pattern of staining very similar to that produced with antisera directed against the primary afferent derived, putative neurotransmitter, vasoactive intestinal polypeptide. Labeled axons and terminals were concentrated in lamina I and V and there was dense fiber staining in t...

Background: Cisplatin is commonly used against several solid tumors. Severe peripheral neuropathy is a major clinical issue affecting 1040% of patients treated with cisplatin and is associated with apoptosis of sensory dorsal root ganglia. Vitamin E is one of the several substances with suggested effects on peripheral nerves but still its exact benefit is not clear. The aim of this study is to ...