OBJECTIVES To review transabdominal esophagocardiomyotomy (surgical treatment of achalasia) of the esophagus and to compare outcomes of partial anterior vs partial posterior fundoplication. DATA SOURCES An electronic search was conducted among studies published between January 1976 and September 2011 using the keywords achalasia, myotomy, antireflux surgery, and fundoplication. STUDY SELECT...

BACKGROUND Although the long-term results of open fundoplication for gastroesophageal reflux disease are well documented, few reports exist on the long-term results of laparoscopic fundoplication. DESIGN Retrospective study with clinical evaluation or mailed survey for patients unable to return to the hospital center. SETTING Multicenter studies (ie, private medical centers, institutional h...

INTRODUCTION Gastroesophageal reflux (GERD) is common in neurologically impaired (NI) children. Fundoplication and gastrostomy have previously been indicated in NI children with GERD who have not responded to medical treatment. The most common reason for fundoplication failure is intrathoracic migration of the wrap. OBJECTIVE The aim of the study is to measure the effect of wrap fixation on t...

BACKGROUND Diminished ovarian reserve (DOR) is one of the causes of infertility in young women. In this prospective study, gene expression profiling (GEP) of corona radiata cells (CRC) was performed to identify genes deregulated in DOR patients. METHODS Microarray-based GEP of CRC isolated from eight women undergoing IVF was performed to identify genes differentially expressed between patient...

The Nissen fundoplication is well established as the surgical treatment for medically refractory gastroesophageal reflux (GER) in childhood. Recurrent GER following fundoplication is a challenging problem with a reported incidence ranging from 0% to 12%. From January 1974 to January 1989, 286 children have been treated for GER with Nissen fundoplication and gastrostomy tube placement at the Uni...

OBJECTIVE To examine the impact of fundoplication on reflux related hospital admissions for children with neurological impairment. DESIGN Retrospective, observational cohort study. Setting 42 children's hospitals in the United States. PARTICIPANTS 3721 children with neurological impairment born between 2000 and 2005 who had at least one hospital admission at a study hospital before their fu...

Although thyroid hormone (TH) is known to exert important effects on the skeleton, the nuclear factors constituting the TH receptor coactivator complex and the molecular pathways by which TH mediates its effects on target gene expression in osteoblasts remain poorly understood. A recent study demonstrated that the actions of TH on myoblast differentiation are dependent on diabetes- and obesity-...