because of participation in many aspects of human life, and due to oxidation-sensitive characteristics of dopamine (da) and arachidonoyl dopamine (aa-da), the necessity of biocompatible carrier to keep them against oxidation is of importance. in this work, we explored the putative binding sites of da and aa-da to -lactoglobulin (blg) as potent carrier. docking results identified the binding si...

There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to ...

Phosphate deprivation results in a resistance to the phosphaturic effect of parathyroid hormone. Dopamine is phosphaturic and is synthesized by kidney proximal tubule, the nephron subsegment where parathyroid hormone inhibits phosphate transport. Thus, to test the hypothesis that phosphate deprivation is associated with low intrarenal dopamine synthesis and that dopamine infusion will overcome ...

ingestion and inhalation of phosphine are 2 forms of toxicity and their clinical manifestation is extremely wide. a 22-year-old girl was admitted with complaints of nausea, vomiting and epigastric pain after eating lunch. she had a history of celiac disease. on arrival, she was alert and hemodynamically stable. there was not any abdominal tenderness or guarding. food poisoning treatment initiat...

Accumulated dopamine (DA) is believed to be detrimental to the brain. EGb761 and FK506 have been reported to possess neuroprotective efficacy. This study attempted to investigate the metabolic pathway of dopamine and to realize whether the synergistic effect would be achieved when EGb761 co-administrated with FK506. Dynamic changes of dopamine and its metabolites including 3, 4-dihydroxyphenyla...

Food can act as a powerful stimulus, eliciting metabolic, behavioural and developmental responses. These phenotypic changes can alter ecological and evolutionary processes; yet, the molecular mechanisms underlying many plastic phenotypic responses remain unknown. Here we show that dopamine signalling through a type-D(2) receptor mediates developmental plasticity by regulating arm length in pre-...

We studied the metabolic pathways of dihydroxyphenylalanine (DOPA) and dopamine as well as the cardiovascular and renal responses to a single administration of DOPA (500 mg orally) in stable essential hypertension. We found that after DOPA, stable hypertensive patients compared with controls showed more blood pressure decrease without reflex tachycardia, had lower creatinine clearance but a hig...

Ischemic myocardial injury was quantified as the sum of S-T segment elevations in epicardial electrocardiogram recordings (2S-T) following acute coronary artery occlusions in 17 dogs. 2S-T rose from 3 ± 1 mv to 26 ± 4 mv (P < 0.001) following occlusion. Myocardial contractility was similarly stimulated by intravenous infusions of dopamine or calcium. At reocclusions of the coronary artery, 2S-T...

We directly measured the net pulmonary extraction of circulating norepinephrine, epinephrine and dopamine in control patients and patients with primary or secondary pulmonary hypertension. Mixed pulmonary artery norepinephrine, epinephrine and dopamine were 314 ± 13 pg/ml, 102 ± 9 pg/mI, 51 ± 5 pg/mi, respectively, for the control group; values were similar in patients with pulmonary hypertensi...