ATTENUATION OF ANTAGONIST-INDUCED IMPAIRMENT IN DOPAMINE RECEPTOR ONTOGENY BY L-PROLYL-L-LEUCYL-GLYCINAMIDE by Mohamad Iqbal Saleh, M.D. It has been shown by others that the prenatal treatment of rats with haloperidol, a dopamine D2 receptor antagonist, leads to a permanent reduction in the number of striatal dopamine D2 receptors in adulthood. Conversely, postnatal treatment of lactating dams ...

Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quinpirole, but not SKF-238393, a D(1) agonist. The effect of dopamine was blocked...

INTRODUCTION Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. It has been shown that the dopaminergic system plays a role in migraine. SD has been suggested as a critical phenomenon in the pathophysiology of migraine. The aim of this study was to investig...

BACKGROUND/OBJECTIVE In the present study, the effect of acute lead exposure in the presence and absence of dopamine or alpha (alpha)-adrenoceptor agents on contractile response of rat isolated thoracic aorta was studied. METHODS Male Wistar rats were used in all experiments. Thoracic aorta was carefully removed, cleaned, and cut into 2-mm thick rings. The rings were mounted for measurement o...

BACKGROUND Although animal studies have raised the possibility that prolactin-elevating dopamine antagonists used to treat psychotic disorders may initiate and promote breast cancers, epidemiologic studies in humans have been limited and inconsistent. METHODS A retrospective cohort study was conducted of 52 819 women exposed and 55 289 not exposed to dopamine antagonists between January 1, 19...

The aim of this study was to examine behavioral and biochemical effects of nafadotride, the new dopamine D3 receptor antagonist, and to compare it with haloperidol (dopamine D2 receptor antagonist) and clozapine (predominate dopamine D4 receptor antagonist). Each drug was injected to adult male Wistar rats intraperitoneally, each at a single dose and for 14 consecutive days. Thirty minutes afte...

To examine the role of dopamine receptor subtypes mediating analgesic and motor responses to opioids, rats were pretreated with either saline or a selective D-1 or D-2 dopamine receptor antagonist 10 min prior to morphine (12 mg/kg IP). Analgesic response latency was determined using the hot plate test (52.5 degrees C and 55 degrees C), and catalepsy was assessed using the abnormal posture test...

Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with complex etiology. Among the neurotransmitter abnormalities that have been investigated in AD, dopaminergic system has intensively studied as key involved emotion and cognition. The undergoes several changes during neuropathological aging process. In general, some studies suggested dopamine plays major role syna...

Introduction: Effects of stress on nervous system activity and development are well defined. In the present study, the effects of maternal stress on dopamine-related behavior in the offspring were studied. Methods: Female pregnant Wistar rats (200 g) were randomly exposed to the noise pollution stress (125 db) for 14 days (5 min/day). The time of exposure was random in order to avoid adaptat...

Several external and internal factors contribute to the reproductive success of teleosts, which makes process complex unique. In Indian freshwater catfish, Heteropneustes fossilis, monsoon plays a crucial role as it fine tunes neuroendocrine axis, culminating in oocyte maturation. Therefore, induction maturation requires coordinated interaction among hypothalamic, hypophyseal, peripheral hormon...