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The major factor influencing the outcome of thrombolytic therapy for acute myocardial infarction is the " door to needle " time. For every hour that thrombolytic treatment is delayed after the onset of symptoms, 1.6 lives are lost per 1000 patients treated. 1 In many institutions the door to needle time exceeds one hour. Various attempts have been made to reduce unacceptable treatment delays. T...

Dear editor: cute myocardial infarction is one of the most prevalent causes of hospitalization in emergency department. In United States 650,000 patients annually suffer from acute myocardial infarction and in Iran ischemic heart diseases are considered as the second cause of mortality in population of 15-49 years (1). Taking thrombolytic drugs leads to 40-50% decrease in mortality rate of such...

BACKGROUND AND PURPOSE Little is known about intravenous recombinant tissue plasminogen activator (rtPA) use in China. By accessing the Chinese National Stroke Registry (CNSR), the rate of intravenous rtPA use was reviewed. We specifically examined the issues of prehospital and in-emergency department delay and compared them with the published data from developed countries. METHODS Funded by ...

background: in patients with acute ischemic cerebral infarction, thrombolytic therapy using intravenous tissue plasminogen activator (iv?tpa) necessitates precise documentation of symptoms’ onset. the aim of this study was to identify major barriers related to the iv?tpa injection in such patients. materials and methods: between 2014 and 2015, patients with definitive diagnosis of acute cerebra...

OBJECTIVE To identify the effect on door to needle (DTN) time of moving the site of thrombolysis delivery from the coronary care unit (CCU) to the emergency department (ED). To ascertain if moving the site of thrombolysis enables appropriate use of thrombolysis. DESIGN Prospective cohort study. SETTING CCU and ED of a 450 bed Scottish district general hospital without on-site primary angiop...

Ischaemic stroke can result in approximately 2 million brain neurones being damaged for each minute that it is left untreated. Various trials and studies such as the National Institute of Neurologic Disorders (NINDS) trial, the European Cooperative Acute Stroke Study (ECASS), ECASS II, and the Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke (ATLANTIS) study have cl...

Better outcomes are obtained with stroke thrombolysis the more rapidly it is given, both in terms of the patient's level of functional ability and also mortality. Current UK performance targets (outside London) aim for a time of 45 minutes or less. Thrombolysis pathways involve multidisciplinary working across departmental boundaries as well as senior level decision making. Our system used tele...

OBJECTIVE To measure the promptness of antibiotic treatment in children with meningococcal disease. METHODS "Door to needle time" for parenteral antibiotics in children with meningococcal disease was recorded prospectively as part of a larger study. The time from arrival at hospital until the first dose of parenteral antibiotics was recorded in 100 children with meningococcal disease (median ...