نتایج جستجو برای: domperidone
تعداد نتایج: 616 فیلتر نتایج به سال:
Domperidone is a dopamine D2 receptor antagonist acting on the chemoreceptor trigger zone in the medulla and also in the gut, causing antiemetic and gastrokinetic effects respectively. In the past, domperidone was considered largely safe, with many indications and few contraindications listed in the product literature. In 2014, Domperidone became indicated only for the prevention of nausea and ...
OBJECTIVE To compare the effects of metoclopramide and domperidone on the breast milk output of mothers with infants in neonatal intensive care. DESIGN Double-blind randomised controlled trial. SETTING Tertiary level neonatal intensive care unit (NICU). SAMPLE Eighty mothers expressing breast milk for their infants (mean gestational age 28 weeks) based in NICU and the amounts expressed fe...
The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the ...
INTRODUCTION Domperidone is a dopamine receptor antagonist with peripheral prokinetic and central antiemetic properties. Prolongation of the QTc interval with chronic use of oral domperidone in standard doses has been reported in the literature. Our goal was to investigate cardiac toxicity in patients receiving 2-fold greater doses than in previous reports. METHODS A retrospective chart revie...
Background: One of the most common functional problems in children is abdominal pain (FAP), and dysmotility one possible causes FAP. Domperidone a prokinetic drug that increases gastrointestinal motility. Objectives: The aim this study was to evaluate effect domperidone on treatment FAP children. Methods: In double-blind clinical trial study, diagnosed 80 aged 5 - 14 years, who were referred Am...
BACKGROUND & OBJECTIVE: There is inconsistent evidence on using antiemetic drugs (ondansetron and domperidone) in children with vomiting associated gastroenteritis having dehydration. The study's objective was to compare the effectiveness of oral domperidone ondansetron for treating during acute either mild or moderate dehydration.
 METHODOLOGY: This non-controlled quasi-experimental s...
INTRODUCTION The use of prokinetic agents on post-pyloric placement of spiral nasojejunal tubes is controversial. The aim of the present study was to examine if metoclopramide or domperidone can increase the success rate of post-pyloric placement of spiral nasojejunal tubes. METHODS A multicenter, open-label, randomized, controlled trial was conducted in seven hospitals in China between April...
AIM To investigate the incidence of nocturnal dyspeptic symptoms in patients with functional dyspepsia (FD) and whether prokinetic drugs can alleviate them. METHODS Eighty-five consecutive Chinese patients with FD were included in this study. One week after single-blinded placebo run-in treatment, baseline nocturnal intragastric pH, bile reflux and nocturnal dyspeptic symptoms of eligible pat...
OBJECTIVES To determine the effect of the drug combination domperidone and pseudoephedrine on nocturnal oximetry measurements and daytime sleepiness in patients with obstructive sleep apnea. METHODS We recruited patients with severe snoring and apneic episodes willing to undergo repeated nocturnal oximetry testing. Following baseline clinical history, Epworth Sleepiness Scale administration, ...
A simple and sensitive fluorescence detection of domperidone by ultra fast liquid chromatographic method was developed and validated in human serum. For the evaluation of new drug delivery systems, conducting of pharmacokinetic studies in human volunteers is essential for approval to marketing after preclinical evaluation in animal models. The present method consists of protein precipitation, e...
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