G17 has growth promoting and antiapoptotic effects on the AR4-2J pancreatic acinar cell line. We previously reported that whereas MAPK regulates G17-stimulation of AR4-2J cell proliferation, Akt mediates the antiapoptotic action of G17. We examined the signal-transduction pathways mediating G17 stimulation of AR4-2J cell growth and survival. G17 activated the small GTP binding proteins Ras, Rac...

BACKGROUND Deoxyelephantopin (DOE) is a natural bioactive sesquiterpene lactone from Elephantopus scaber, a traditionally relevant herb in Chinese and Indian medicine. It has shown promising anticancer effects against a broad spectrum of cancers. METHODS We examined the effect of DOE on growth, autophagy, apoptosis, cell cycle progression, metastasis, and various molecular signaling pathways ...

In the present study a deterministic bio-economic model was used to estimate economic values for reproduction traits (conception rate, twining rate and litter size), production traits (body weight of kid sold at 6.5 months, annual cashmere weight, body weight of doe and annual milk yield) and longevity (survival of doe, survival of kid until weaning and survival of kid until sale age at 6.5 mon...

heat exchangers are one of the most important devices of mechanical systems in modernsociety. most industrial processes involve the transfer of heat and more often they requirethe heat transfer process to be controlled. a heat exchanger is the heat exchanged betweentwo media, one being cold and the other being hot. there are different types of heatexchanger, but the type which is widely used in...

A pancreatic acinar cell line, AR4-2J, that expresses a high density of substance P (SP)-binding sites has been identified. SP-binding sites on intact AR4-2J cells were detected with 125I-Bolton-Hunter SP (125I-BHSP). 125I-BHSP binding to AR4-2J cells has an apparent Kd of 40 pm with slow rates of association and dissociation. The number of high affinity binding sites was about 10(4)/cell. Bind...

Degradation of Acid Red 4 (AR4) by photocatalytic processes with TiO2 nanotube arrays (TNTs) of various dimensions was carried out in this study. TNTs was fabricated by the anodization of titanium foil in electrolyte containing fluoride. The dimension and the induced photocurrent of TNTs were determined by a field-emission scanning electron microscopy and a potentialstat/galvanostat, respective...

Phase change memory (PCM) technology appears as more scalable than DRAM technology. As PCM exhibits access time slightly longer but in the same range as DRAMs, several recent studies have proposed to use PCMs for designing main memory systems. Unfortunately PCM technology suffers from a limited write endurance; typically each memory cell can be only be written a large but still limited number o...

prediction of climatic variables on a local scale by general circulation models of the atmosphere is impossible because the models have large-scale network of resolution. therefore, downscaling methods are used to solve this problem. since the climate change phenomenon can affect different systems such as, water resources, agriculture, environment, industry and economy as well, selection of the...