نتایج جستجو برای: dna mitochondrial

تعداد نتایج: 613263  

حیدری, محمد مهدی , خاتمی, مهری,

Introduction: The mitochondrial defects in Friedreich ataxia (FRDA) have been reported in many researches. Friedreich ataxia is an autosomal recessive neurodegenerative disorder caused by decreased expression of the Frataxin protein. Frataxin deficiency leads to excessive free radical production and dysfunction of respiratory chain complexes. Mitochondrial DNA (mtDNA) could be considered as a c...

Journal: :Nucleic acids research 2001
S L Donahue B E Corner L Bordone C Campbell

The Saccharomyces cerevisiae CDC9 gene encodes a DNA ligase protein that is targeted to both the nucleus and the mitochondria. While nuclear Cdc9p is known to play an essential role in nuclear DNA replication and repair, its role in mitochondrial DNA dynamics has not been defined. It is also unclear whether additional DNA ligase proteins are present in yeast mitochondria. To address these issue...

Journal: :Genetics 2006
Rhiannon E Lloyd Joon-Hee Lee Ramiro Alberio Emma J Bowles João Ramalho-Santos Keith H S Campbell Justin C St John

Mitochondrial DNA is an extranuclear genome normally maternally inherited through the oocyte. However, the use of nuclear transfer can result in both donor cell and recipient oocyte mitochondrial DNA persisting through to blastocyst and being transmitted to the offspring. The degree of donor mitochondrial DNA transmission appears to be random and currently no evidence exists to explain this phe...

2016
Gael L. M. Cagnone Te-Sha Tsai Yogeshwar Makanji Pamela Matthews Jodee Gould Michael S. Bonkowski Kirstin D. Elgass Ashley S. A. Wong Lindsay E. Wu Matthew McKenzie David A. Sinclair Justin C. St. John

An increasing number of women fail to achieve pregnancy due to either failed fertilization or embryo arrest during preimplantation development. This often results from decreased oocyte quality. Indeed, reduced mitochondrial DNA copy number (mitochondrial DNA deficiency) may disrupt oocyte quality in some women. To overcome mitochondrial DNA deficiency, whilst maintaining genetic identity, we su...

Journal: :Journal of cell science 1990
S Sazer S W Sherwood

Cell growth and division require the doubling of cellular constituents followed by their equal distribution to the two daughter cells. Within a growing population, the ratio of mitochondrial to cellular volume is maintained, as is the number of mitochondrial genomes per cell. The mechanisms responsible for coordinating nuclear and mitochondrial DNA synthesis, and for balancing increases in cell...

Journal: :Kidney & blood pressure research 2016
Cheuk-Chun Szeto Ka-Bik Lai Kai-Ming Chow Bonnie Ching-Ha Kwan Phyllis Mei-Shan Cheng Vickie Wai-Ki Kwong Agnes Shin-Man Choy Chi-Bon Leung Philip Kam-Tao Li

BACKGROUND/AIMS Circulating bacterial DNA fragment is related to systemic inflammatory state in peritoneal dialysis (PD) patients. We hypothesize that circulating mitochondrial DNA, which has a similar structure with bacterial DNA, correlates with systemic inflammatory state and predicts cardiovascular event in new PD patients. METHODS We measured plasma mitochondrial DNA level by quantitativ...

Journal: :Genetics 1990
M Mirfakhrai Y Tanaka K Yanagisawa

Restriction fragment length polymorphisms (RFLPs) were used as markers to monitor mitochondrial inheritance in the cellular slime mold, Polysphondylium pallidum. When two opposite mating types (mat1 and mat2) of closely related strains were crossed, all the haploid progeny regardless of mating type inherited their mitochondrial DNA from the mat2 parent only. When opposite mating types from more...

2010
Ricardo Gredilla

During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging. Aging is a multifactorial phenomenon characterized by increased susceptibility to cellular loss and functional decline, where mitochondrial DNA mutations and mitochondrial DNA d...

2014
Bartosz Szczesny Attila Brunyanszki Gabor Olah Sankar Mitra Csaba Szabo

The positive role of PARP1 in regulation of various nuclear DNA transactions is well established. Although a mitochondrial localization of PARP1 has been suggested, its role in the maintenance of the mitochondrial DNA is currently unknown. Here we investigated the role of PARP1 in the repair of the mitochondrial DNA in the baseline and oxidative stress conditions. We used wild-type A549 cells o...

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