Electrically controllable deoxyribonuclic acid (DNA) nanolevers are used to investigate the binding interaction between Influenza A/Aichi/2/1968 and peptide called “PeB”, which specifically binds viral surface protein hemagglutinin. PeB is immobilized on gold electrodes of a “switchSENSE” biochip by conjugation DNA-strands that hybridized complementary anchors. The surface-tethered DNA strand c...

in depth interaction studies between calf thymus deoxyribonucleic acid (ct-dna) and a series of four structurally relative palladium(ii) complexes [pd(en)(hb)](no3)2 (a-d), where en is ethylenediamine and heterocyclic base (hb) is 2,2'-bipyridine (bpy, a); 1,10-phenanthroline (phen, b); dipyridoquinoxaline (dpq, c) and dipyridophenazine (dppz, d) (figure 1), were performed. these studies h...

Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range...

aim : evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research.   background : in clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. since the...

This review analyzed the literature data on in vitro preclinical study of cytotoxic properties organotin compounds, as well main mechanisms their action. The latter consist interacting with SH groups proteins, initiating oxidative stress, binding to DNA, receptors, activate apoptosis by increasing expression caspases, proapoptotic and decreasing antiapoptotic proteins. Organotin depending donor...