BACKGROUND Disulfiram implantation is a widely used treatment alternative for alcohol abuse, yet reports on the surgical aspect of disulfiram implantation with respect to patient and drug-related treatment efficacy and wound complications are very limited. We present our clinical experiences with disulfiram implantation and discuss the surgical outcomes obtained with different anatomical planes...

Drug intoxication with disulfiram is a rare condition that may lead to severe and potentially fatal cardiovascular manifestations such as cardiogenic shock. We report the case of a female patient with refractory shock after deliberate self-poisoning with disulfiram. Clinical, biochemical and echocardiographic assessment, as well as invasive monitoring confirmed cardiogenic shock associated with...

Dear Editor, Disulfiram has been established as one of the few pharmacological treatments for alcohol dependence since 1947. Rare neuropsychiatric complications associated with disulfiram have been reported in case studies, but these were related to intoxication and drug interaction with other medications. Here we report a case of encephalopathy in a middle-aged Chinese man who was taking disul...

Disulfiram [bis(diethylthiocarbamoyl)disulphide] is an antabuse drug, being used clinically as an aid to the treatment of chronic alcoholism. It is the first drug approved by US Food and Drug Administration to treat the alcohol addiction [1]. Alcohol (ethanol) transforms into acetaldehyde by alcohol dehydrogenase enzyme, which further oxidized to acetic acid by acetaldehyde dehydrogenase (ADH) ...

Based on reporting in the last several years, an impressive but dismal list of cytotoxic chemotherapies that fail to prolong the median overall survival of patients with glioblastoma has prompted the development of treatment protocols designed to interfere with growth-facilitating signaling systems by using non-cytotoxic, non-oncology drugs. Recent recognition of the pro-mobility stimulus, inte...

Use of Disulfiram under supervision in well-motivated alcoholics is effective in reducing relapse rates. Several adverse effects, some of them life-threatening, have been reported due to the drug. An awareness of the adverse effects is useful to keep a follow up and sustain patient compliance with the drug. This study of 158 out patients on daily oral disulfiram revealed that though many patien...

Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...