We have characterized 31 mutations in the gld-1 (defective in germline development) gene of Caenorhabditis elegans. In gld-1 (null) hermaphrodites, oogenesis is abolished and a germline tumor forms where oocyte development would normally occur. By contrast, gld-1 (null) males are unaffected. The hermaphrodite germline tumor appears to derive from germ cells that enter the meiotic pathway normal...

In this paper, we investigate an efficient encoding approach for generalized low-density (GLD) parity check codes, a generalization of Gallager’s low-density parity check (LDPC) codes. We propose a systematic approach to construct approximate upper triangular GLD parity check matrix which defines a class of efficientencoding GLD codes. It’s shown that such GLD codes have equally good performanc...

The maternal-effect sterile (MES) proteins are maternally supplied regulators of germline development in Caenorhabditis elegans. In the hermaphrodite progeny from mes mutant mothers, the germline dies during larval development. On the basis of the similarities of MES-2 and MES-6 to known transcriptional regulators and on the basis of the effects of mes mutations on transgene expression in the g...

This paper reports a complete system for modeling, representation, and validation of geometric tolerances, using feature-based approach from boundary representation (B-Rep) based solid models. The utility of feature based representation scheme for representing Geometric Dimensioning and Tolerancing (GDT) information in geometric models is highlighted. Explicit information from B-Rep is culled u...

The FBF RNA binding proteins control multiple aspects of C. elegans germline development, including sex determination. FBF promotes the oocyte fate at the expense of spermatogenesis by binding a regulatory element in the fem-3 3'UTR and repressing this sex-determining gene. Here we report the discovery of GLD-3, a Bicaudal-C homolog and cytoplasmic protein that physically interacts with FBF. Us...

Post-transcriptional gene regulation mechanisms decide on cellular mRNA activities. Essential gatekeepers of post-transcriptional mRNA regulation are broadly conserved mRNA-modifying enzymes, such as cytoplasmic poly(A) polymerases (cytoPAPs). Although these non-canonical nucleotidyltransferases efficiently elongate mRNA poly(A) tails in artificial tethering assays, we still know little about t...

The tolerancing step has a great importance in the design process. It characterises the relationship between the different sectors of the product life cycle: Design, Manufacturing and Control. We can distinguish several methods to assist the tolerancing process in the design. Based on arithmetic and statistical method, this paper presents a new approach of analysis and verification of tolerance...

Messenger RNA translation is regulated by RNA-binding proteins and small non-coding RNAs called microRNAs. Even though we know the majority of RNA-binding proteins and microRNAs that regulate messenger RNA expression, evidence of interactions between the two remain elusive. The role of the RNA-binding protein GLD-1 as a translational repressor is well studied during Caenorhabditis elegans germl...

An important event in the development of the germline is the initiation of meiotic development. In Caenorhabditis elegans, the conserved GLP-1/Notch signaling pathway regulates the proliferative versus meiotic entry decision, at least in part, by spatially inhibiting genes in the gld-1 and gld-2 parallel pathways, which are proposed to either inhibit proliferation and/or promote meiotic develop...

computation of the second order delay in rc-tree based circuits is important during the design process of modern vlsi systems with respect to having tree structure circuits. calculation of the second and higher order moments is possible in tree based networks. because of the closed form solution, computation speed and the ease of using the performance optimization in vlsi design methods such as...