CONTEXT Bitter taste, as well as dissolve time, presents a significant challenge for the acceptability of formulations for oral transmucosal drug delivery. OBJECTIVE To characterize a novel sublingual tablet formulation of buprenorphine/naloxone with regards to pharmacokinetics, dissolve time and formulation acceptability. METHODS Dry mixing techniques were employed to produce a small and f...

Content objects are essential links between Knowledge Management and E-Learning systems. Therefore content authoring and sharing is an important, interdisciplinary topic in the resp. fields. In this paper, we want to critically elaborate on the “user as producer and consumer”-concept for content production and consumption. We address the subject by using the notion of content collaboration as e...

Cross-sectional transmission electron microscopy was used to study defect formation and evolution in the !001" Ge and Si wafers implanted with 1 MeV Si+ and 40 keV Si+ at a dose of 1 !1014 cm−2. As expected, upon annealing, the #311$ extended defects form and subsequently dissolve at the projected range for nonamorphizing implants into Si. However, in Ge, no #311$ defect formation is observed f...

It is well-known that the harsh operational conditions of turbine blades lead to a gradual change in the microstructure of underlying Ni-based superalloy of blades. According to this, a rejuvenation process should be conducted on turbine blades superalloys to recover their microstructures. The first and main step of rejuvenation process is the determination of appropriate solution condition in ...