Dissolution testing of the drug formulation introduced in 1960 since then the importance of dissolution test has grown rapidly as have the number of tests and demands in quality control laboratories. Dissolution testing is an official test used by pharmacopeias for evaluating drug release of solid and semisolid dosage forms. The main applications of the dissolution testing include biopharmaceut...

Dissolution kinetics of the (110) face of salicylic acid in aqueous solution is determined by hopping intermittent contact scanning electrochemical microscopy (HIC-SECM) using a 2.5 μm diameter platinum ultramicroelectrode (UME). The method operates by translating the probe UME towards the surface at a series of positions across the crystal and inducing dissolutio n via the reduction of protons...

A new specific, accurate, precise, and reproducible selective online dissolution method for rosiglitazone maleate is developed and validated for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The rationale of the method is based on the direct measurement of the absorbance of the analyte in the buffer medium at 242 nm using buffer as blank. Dissolution is achieved on a ...

Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency ...

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes...

Ethylenediamine tetraacetate (EDTA)-mediated calcite dissolution occurs via a different process than water-promoted dissolution. Near-atomic-scale observations in EDTA solutions demonstrate that, after penetration through a critical pit depth barrier, step velocity increases linearly with pit depth for EDTA-promoted dissolution. The parallel processes of water-dominated dissolution at point def...

Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. The aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000. The effect of solubilization by...

Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...

The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...

Irbesartan, a widely prescribed anti hypertensive drug belongs to class II under BCS classification and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It needs enhancement in the dissolution rate in its formulation development. Complexation with β-cyclodextrin (βCD) and use of Crospovidone and PVP K 30 are tried for enhancing the dissolution rate of irbesartan...