Abstarct: This study was carried out to compare the binding effects of rice and wheat starches with that of the official starch; maize starch BP. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner’s ratio, Carr’s index and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard metho...

In the following study starch was isolated from the dried pulp of unripe pappaya fruit (Carica pappaya). The isolated starch was used as a binder in different concentrations in diclofenac sodium tablets. The tablets were formed by wet granulation method by using 2% w/v, 4% w/v, 6% w/v, 8% w/v and 10% w/v pappaya starch as binding agent. Formulated diclofenac sodium tablets were further evaluate...

Domperidone Maleate (DOM), an antiemetic drug, has been used in treatment of adults and children. It has low aqueous solubility and hence low bioavailability. In present study, an attempt has been made to enhance the solubility of DOM by inclusion complexation with Hydroxypropyl-βCyclodextrin (HP-β-CD) using kneading technique and formulation of fast disintegrating tablets by using Sodium Starc...

Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of zidovudine, an antiretroviral drug, were prepared using different superdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) and sodium starch glycollate by direct compression metho...

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content u...

For industrially manufactured pharmaceutical dosage forms, product quality tests and performance tests are required to ascertain the quality of the final product. Current compendial requirements specify a disintegration and/or a dissolution test to check the quality of oral solid dosage forms. These requirements led to a number of compendial monographs for individual products and, at times, the...