Abstract: Despite several topical and systemic antifungal drugs are used for the treatment of fungal infection, Amphotericin B (AmB) is still one of the most common first-line choices in systemic fungal infection for over seventh decades from discovery. Amphotericin B which is belonged to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. Its mechanism of antifunga...

The main purpose of this paper is the construction of explicit Gauss-Turán quadrature formulas: they are relative to some classes of weight functions, which have the peculiarity that the corresponding s-orthogonal polynomials, of the same degree, are independent of s. These weights too are introduced and discussed here. Moreover, highest-precision quadratures for evaluating Fourier-Chebyshev co...

Interactions are explored through the observation of the dynamics of particles. On the classical level the basic underlying assumption in that scheme is that Newton's second law holds. Relaxing the validity of this axiom by, e.g., allowing for higher order time derivatives in the equations of motion would allow for a more general structure of interactions. We derive the structure of interaction...

Background: Date (Phoenix dactylifera L.) is one of the most important agricultural crops in Iran. This study was carried out to determine the possibility of using date paste for manufacturing a new ready-to-eat food product. Methods: Various formulations were prepared by mixing Mazafati date paste, bread, oil (animal and olive), nuts and spices but only six formulas were chosen according to s...

We revisit the problem of extending quadrature formulas for general weight functions, and provide a generalization of Patterson’s method for the constant weight function. The method can be used to compute a nested sequence of quadrature formulas for integration with respect to any continuous probability measure on the real line with finite moments. The advantages of the method include that it w...

Different buckling failure modes of stiffened panels will result in differences ultimate strengths. In this study, the benchmark model bottom bulk carrier with appropriate initial imperfections, boundary conditions and mesh size are selected for a series non-linear FE analyses. A mode discrimination method considering change rule strength stress strain distribution plates limit state is propose...

The correspondence of various spectral difference error metrics to human discrimination data was investigated. Time-varying harmonic amplitude data were obtained from the spectral analysis of eight musical instrument sounds (bassoon, clarinet, flute, horn, oboe, saxophone, trumpet, and violin). Sounds were resynthesized with various levels of random spectral alteration, ranging from 1 to 50%. L...

conversations contain spontaneous use of routine formulas which lets speaker sinteract with each other to express opinions. gambits, as one of these formulas, act as an opening remark and help speakers to maintain the smooth flow of an everyday conversation. the lack of mastery of using gambits in maintaining the conversation leads to breakdowns in speaking. this paper aimedat comparingthe use ...