This paper presents a computational method for designing assemblies with a built-in disassembly pathway that maximizes the profit of disassembly while satisfying regulatory requirements for component retrieval. Given component revenues and components to be retrieved, the method simultaneously determines the spatial configurations of components and locator features on the components, such that t...

In this study, we propose an intelligent automated disassembly cell for online (real time) selective disassembly. The cell is composed of an industrial robotic manipulator, a camera, range sensing and component segmentation visual algorithms. The cell prototype allows for robotic sensory-driven disassembly under uncertainty. An online genetic algorithm model for selective disassembly is also pr...

Several strategies have been detected in the extant literature to understand how Circular Economy (CE) can be pursued. Considering all End-of-Life (EoL) management practices detected, disassembly processes identified as strategic. However, only scattered attempts explored digital technologies (specifically, simulation) support CE adoption, by focusing on processes. This research detects, throug...

A green design for assembly model is presented to integrate design evaluation and assembly and disassembly sequence planning by evaluating the three activities in one integrated model. For an assembled product, an assembly sequence planning model is required for assembling the product at the start of the product life cycle. A disassembly sequence planning model is needed for disassembling the p...

The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disassembly is mediated by phosphorylation, but the precise molecular mechanism is s...

The objective of the Disassembly Line Balancing Problem (DLBP) is to use the resources of the disassembly line as efficiently as possible while meeting the demand. This issue is hard to attempt due to the inherent uncertainties that occur during the process. Starting from real industrial examples, this article presents a simple-to-apply method to accomplish the balancing of complex disassembly ...

Using sea urchin embryonic and in-vitro-assembled nuclei incubated in sea urchin mitotic extract, I provide evidence for a requirement for functional nuclear pores and a nuclear lamina for nuclear envelope disassembly in vitro. In interphase gastrula nuclei, lamin B interacts with p56, an integral protein of inner nuclear membrane cross-reacting with antibodies to human lamin B receptor. Incuba...

In this paper we consider the problem of designing a mixed assembly–disassembly line for remanufacturing. That is, parts from the disassembly and repair of used products can be used to build “new” products. This is a problem common to many OEM remanufacturers, such as Xerox or Kodak. We study two main configurations, under the assumption that the disassembly sequence is exactly the reverse of t...

Molecular markers of the zebrafish inner nuclear membrane (NEP55) and nuclear lamina (L68) were identified, partially characterized and used to demonstrate that disassembly of the zebrafish nuclear envelope requires sequential phosphorylation events by first PKC, then Cdc2 kinase. NEP55 and L68 are immunologically and functionally related to human LAP2beta and lamin B, respectively. Exposure of...

Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex. Unexpectedly, subsequent myelin wrapping coincides with the upregulation of ...