Rabbit anti-thymocyte globulin is used worldwide to treat and prevent rejection in kidney transplantation. Multiple mechanisms of action of this polyclonal preparation are responsible for its success. Studies have supported clinical benefits of rabbit anti-thymocyte globulin in high immunological risk kidney transplant recipients when used as an induction agent at the time of transplant and for...

Fluorescent antibody methods were originally introduced by Coons and associates in 1942. Included in this first publication was a procedure for antibody-fluorescein conjugation and a description of fluorescent reactions obtaincd by means of ultraviolet light microscopy. This communication, and later ones by other authors, indicated that fluorescent antibody procedures were practical for rapid a...

visceral leishmaniasis (vl) is one of the most important parasitic diseases which is endemic in different parts of iran. serological studies were conducted by direct agglutination test (dat) on 12144 human serum samples, collected from four geographical zones of iran. sero prevalence, geographical distribution, clinical signs and symptoms for human visceral leishmaniasis based on dat for the pe...

Through the use of absorbed idiotypic antisera prepared against single isolated monoclonal IgM anti-gamma-globulins, partial cross-idiotypic specificity was demonstrated with other IgM anti-gamma-globulins. Such antisera classified these proteins into at least three groups. The major group which included 60% of the anti-gamma-globulins was particularly homogeneous. The anti-gamma-globulin speci...

A notable advance in the study of the haemolytic anaemias was made by Boorman, Dodd, and Loutit (1946), who showed that it vwas possible to differentiate between the congenital and acquired types of acholuric jaundice by submitting the washed erythrocytes from these patients to the action of an anti-human globulin serum (Coombs and others, 1945). The erythrocytes of 17 patients with congenital ...

Determination of serum immunoglobulin levels in NZB and normal mice has indicated that an elevation of the gammaM-globulin level occurs in NZB mice. This can be demonstrated in young NZB mice well before other autoimmune manifestations are observed. A slight elevation of gammaM-globulin was also observed in NZB hybrid mice. Erythrocyte autoantibodies were analyzed by the direct Coombs' test wit...

Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhi...

The impact of the intensity of graft-versus-host-disease immunoprophylaxis on transplantation outcomes in patients undergoing transplantation following reduced-intensity conditioning is unclear. This study addresses this issue in 228 adult patients above 50 years of age with acute myeloid leukemia in first complete remission given peripheral blood stem cells from HLA-identical siblings after fl...

, 1072 (2012); 338 Science et al. Augustine Choy Irreversible Atg8 Deconjugation Effector RavZ Inhibits Host Autophagy Through Legionella The This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by P...