Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene. The mutagenicity of 0.05 nmol of B[a]P 7,8-diol-9,10-epoxide-2 in strain TA10...

Two major carotenoids of the stick insect were reinvestigated and shown to be /?,/?-caroten-2-ol and /?,/?-carotene-2,2'-diol and not isocryptoxanthin (/?,/?-caroten-4-ol) and isozeaxanthin (/?,/?-carotene-4,4'-diol). Both pigments are esterified with fatty acids. The identification is based on cochromatography with authentic 2-, 3and 4-isomers of the monoand dihydroxy pigment, mass spectra, an...

Hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. The high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. Androgen effects on spatial memory are complex and contradictory. Some evidence suggests a positive correlation between androgens and spatial memo...

1. Several species of micro-organisms that were capable of utilizing pyridine compounds as carbon and energy source were isolated from soil and sewage. Compounds degraded included pyridine and the three isomeric hydroxypyridines. 2. Suitable modifications of the cultural conditions led to the accumulation of pyridinediols (dihydroxypyridines), which were isolated and characterized. 3. Three spe...

Polyurethanes (PU) have a wide variety of applications due to possessing tailored properties which can be imparted by composition. The combination polyols in different ratios provide specific for the segmented PU, such as mechanical strength, elasticity, hydrophilicity and so on. In this work, amphiphilic polyurethanes, based on poly(ε-caprolactone)diol (PCL-diol) poly(2-ethyl-2-oxazoline)diol ...

The trans-diequatorial 3,4-diol of 2,5-di-O-benzyl-D-chiro-inositol cleaved selectively with the periodate ion in the presence of the trans-diaxial 1,6-diol to give a dialdehyde (dialdose) from which 3,6-di-O-benzyl-D-manno-tetrahydroxyazepane (1) was made. The trans-diaxial 1,6-diol of 3,4-di-O-allyl-2,5-di-O-benzyl-D-chiro-inositol was not cleaved satisfactorily by periodate, but replacement ...

Abbreviations : HMDS, 1,1,1,3,3,3-hexamethyldisilazane; TMCS, trimethylchlorosilane; cholesterol, Cholest-5-en-3b-ol; oxysterols, cholesterol oxidation products; 7-ketocholesterol, cholest-5-en-3b-ol-7-one; cholestanetriol, cholestan-3b,5a,6b-triol; a-epoxycholesterol, cholestan-5a,6a-epoxy-3b-ol; 25-hydroxycholesterol, cholest-5-en-3b,25-diol; 7a-hydroxycholesterol, Cholest-5-en-3b,7a-diol; 7b...

Herein, we report the synthesis and evaluation of a novel family of biodegradable and elastomeric polyesters, poly(diol citrates). Poly(diol citrates) were synthesized by reacting citric acid with various diols to form a covalent cross-linked network via a polycondensation reaction without using exogenous catalysts. The tensile strength of poly(diol citrates) were as high as 11.15+/-2.62 MPa an...

Exposure to bisphenol A (BPA), an environmental contaminant, has been linked to metabolic disorders. However, there are no reports describing the effects of BPA on the profiling of cis-diol metabolites. It is challenge to detect these metabolites in biological samples because of their low abundance, high polarity and serious matrix interference. In this study, a chemical isotope-labeling method...