Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (-)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (-)12a and diethyl{[(3R,5S)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidi...

A colorless, odorless G nerve agent, a type of chemical transfer agent (CWA) that causes significant loss life, is being studied for quick and accurate detection. In this study, detection materials with different functional groups were synthesized based on thiourea (TU)-decorated polyhedral oligomeric silsesquioxane (POSS) to study the most suitable material dimethyl methylphosphonate (DMMP), s...

A major research effort has been devoted over the years for the development of chemical sensors for the detection of chemical and explosive vapors. However, the deployment of such chemical sensors will require the use of multiple sensors (probably tens of sensors) in a sensor package to achieve selective detection. In order to keep the overall detector unit small, miniature sensors with suffici...

The deep oxidation of toxic organics and chemical warfare (CW) agent simulants using Pd/C and dioxygen or hydrogen peroxide at 80−90°C was recently demonstrated by Sen et al. This process offers a chemical means of destroying CW materials in a manner traditionally achievable only by incineration. Our investigations of the common simulant dimethyl methylphosponate (DMMP) have shown mineralizatio...

Using molecular dynamics simulations, we modeled solvation and diffusion in aqueous solutions of organophosphorous compounds, including nerve G-agents sarin and soman (methylphosphonofluoridates) and their common simulants DMMP (dimethyl methylphosphonate) and DIFP (diisopropyl fluorophosphate). The aqueous solutions of the organophosphorous compounds were found to display complex molecular sca...

We report the use of carbon nanotubes as a sensor for chemical nerve agents. Thin-film transistors constructed from random networks of single-walled carbon nanotubes were used to detect dimethyl methylphosphonate ~DMMP!, a simulant for the nerve agent sarin. These sensors are reversible and capable of detecting DMMP at sub-ppb concentration levels, and they are intrinsically selective against i...

Surface-enhanced Raman scattering (SERS) is a powerful spectroscopic technique for selective detection and quantification of molecules at extremely low concentrations. However, practical SERS applications gaseous chemicals with small cross section still in its early stages. We herein report plasmonic-sorbent thin-film platform integrated internal standard outstanding sensing capabilities chemic...

The presence of chemical warfare agents (CWAs) in the environment is a serious threat to human safety, but there are many problems with currently available detection methods for CWAs. For example, gas chromatography–mass spectrometry cannot be used in-field owing rather large size equipment required, while commercial sensors have disadvantages low sensitivity and poor selectivity. Here, we deve...