An efficient green approach for the synthesis of 9-heteroaryl-acridine-1,8-dione derivatives (3a-f) was accomplished via reactions dimedone (1) with various heteroaromatic aldehydes (2a-f) and ammonium acetate through one-pot multicomponent in water under mild conditions using ultrasound irradiation excellent yields. Of synthesized compounds, 3d-f were novel this process presents advantages hig...

Since its discovery almost 40 years ago, S-hydroxylation ( SOH) of cysteine thiol side chains at active and allosteric sites within proteins has emerged as a central post-translational modification. At present, more than 200 transcription factors, signaling proteins, metabolic enzymes, proteostasis regulators, and cytoskeletal components that undergo sulfenic acid modification have been identif...

The synthesis of a novel dihydropyridine derivatives bearing dimedone as an excellent precursor has been achieved by applying three component Hantzsch condensation. The newly synthesized compounds were characterized by IR, NMR, Mass spectra and also by C, H, N analyses. All synthesized compounds undergo docking studies and biological screening for antimicrobial activity against Gram-positive ba...

a simple, efficient, and high yielding one-pot protocol has been developed for the synthesis of 4h-benzo[b]pyrans scaffolds installing a three-component tandem knoevenagel-cyclocondensation reaction of an aldehyde, malononitrile and dimedone using guanidinium chloride as polyfunctional organocatalyst under solvent-free conditions in high to excellent yields. various aromatic aldehydes were util...

Micropuncture technique has contributed to our understanding of renal physiology. Particulary the microphotometric determination of the inulin concentration in tubular fluid collected through a micropunc ture technique is a key point for the analysis of the water movement across the tubular cell membrane. Hilger et al. (1). Vurk and Pergam (2) have developed their methods In the experiment to b...

A practical protocol for the preparation of parallel solution-phase libraries of the quaternary carbon-containing oxazatricycles and spiropyrans is reported. Target compounds were obtained in moderate to excellent yields by an Et(3)N-mediated multicomponent reaction from various N-methylisoquinolium or flavylium salts and 4-hydroxycoumarins or dimedone in acetone. Purification of the final prod...