The liver is an essential metabolic organ. In addition to metabolizing glucose and lipids, hepatocytes also secrete various cytokines that modulate both hepatocyte metabolism and liver inflammation. Hepatocyte injury and death and liver inflammation are the major contributors to liver diseases, including nonalcoholic steatohepatitis (NASH). Anatomic locations have a profound effect on hepatocyt...

Carbohydrates and nutrition 119 Platt, B. S., Miller, D. S. & Payne, P. R. (1961). In Recent Advances in Human Nutrition, p. 351. [J. F. Brock, editor.] London: J. & A. Churchill. Platt, B. S. & Stewart, R. J. C. (1962). Brit. J . Nutr. 16, 483. Rabinowitz, U. & Zierler, K. L . (1963). Nature, Lond., 199, 913. Kandle, P. J., Garland, P. B., Hales, C. N. & Newsholme, E. A. (1963). Lancet, i, 785...

Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulation by an antioxidant supplementation and lipid i...

This article discusses specific dietary factors as well as dietary patterns that affect the major coronary heart disease (CHD) lipid risk factors (ie, LDL-C, HDL-C, and TG). Based on a very large evidence base, it is clear that diet and lifestyle practices can markedly affect these major CHD lipid risk factors, and consequently decrease CHD risk substantively.

BACKGROUND Metabolic diseases in China have been on the rise in recent decades, partially due to reduced cereal consumption and excessive intake of low glycemic index (GI) foods such as meat and oil. Although the relationship between dietary glycemic load (GL) and various metabolic diseases has been extensively studied worldwide, it is unclear whether dietary GL is related to blood lipid levels...

Calorie restriction (CR) has been shown to decrease reactive oxygen species (ROS) production and retard aging in a variety of species. It has been proposed that alterations in membrane saturation are central to these actions of CR. As a step towards testing this theory, mice were assigned to 4 dietary groups (control and 3 CR groups) and fed AIN-93G diets at 95 % (control) or 60 % (CR) of ad li...

background: the prevalence of type 2 diabetes is increasing in malaysia, with most patients poorly controlled. hence, this study aimed to determine nutritional and metabolic status as well as blood pressure of malaysian patients with type 2 diabetes mellitus and identify associated risk factors for poor glycemic control. materials and methods: a total of 104 type 2 diabetic patients were recrui...

Dietary supplementation is an effective means to improve EPA and DHA status. However, it is unclear whether lipid structure affects EPA+DHA bioavailability. We determined the effect of consuming different EPA and DHA lipid structures on their concentrations in blood during the postprandial period and during dietary supplementation compared with unmodified fish oil TAG (uTAG). In a postprandial ...