In this review, we shall outline the basic principles of circular dichroism (CD) indicating the types of structural information relevant to the study of biomolecules, such as proteins or DNA. We are mainly interested to show the utility of this technique to study protein-ligand, DNA-ligand and protein-DNA interactions.

Abstract Gyroid optical metamaterials consist of triply periodic chiral networks that are attractive photonic structures due to the combination intriguing properties and spontaneous self‐assembly‐based fabrication routes using materials such as block copolymers. A previous experimental investigation found gyroid support strong circular dichroism, beyond what simulations only considering bulk in...

Recently, we have made significant improvements in the accuracy of calculations of the circular dichroism of proteins from first principles. The quality of these calculations (especially at 220 nm, a key wavelength, where the intensity of the band correlates well with the helical content of polypeptides) has given us confidence to use such calculations to analyse nanosecond molecular dynamics s...

The interaction of two IR chromophores yields a strong vibrational circular dichroism couplet whose sign reflects the absolute configuration of the molecule. We present a method to determine absolute configuration of a chiral molecule based on this couplet without need of theoretical calculation. Not only can this method analyze various molecules whose absolute configuration is difficult to det...

The photoionization process NO A2Z+(c =0, N=22) NO+ X'Z+(v+=0, lV+)+e is studied with suScient energy resolution that the photoelectron angular distributions associated with individual rotational levels N+ of the ion are determined. By ionizing with left and right circularly polarized light and observing the change in the rotationally resolved photoelectron angular distributions, we can deduce ...

Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem g...