objective(s): leptin exerts various effects on appetite and body weight. disruption of the obesitygene is precedent to fatness. insulin or glucose elevates leptin, but streptozotocin reduces it. however, controversial data exist for the effects of leptin on diabetes and leptin level in each gender. leptin can damage the kidney function but little evidence exists for its hepatic effects. the aim...

objectives: diabetes mellitusmanifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. previousstudies proved that this disease is directly related to hyperglycemia and hyperlipidemia. the aim of this study was to investigate the hypoglycemic and hypolipidemic effects of hydroalcoholic extract of prangos frulacea (l.)lindlin alloxan-induced diabeti...

vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify histological and immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl sulphate (vs)-treated streptozotocin (stz) induced diabetic rats. male wi star rats were made diabetic by injecting a single intravenous dose of stz (40 mg...

background and objective: lowering serum glucose and lipid levels in diabetic patients by using natural materials is of great importance. in this study, the effect of oral consumption of fumaria parviflora lamwas was assessed on serum glucose and lipid levels in streptozocin diabetic rats. materials and methods: in this experimental study, 32 male wistar rats were divided into four groups of co...

background and objective: cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. in this study, the effect of chronic administration of tribulus terrestris (tt) feeding was studied on aortic reactivity of streptozotocin (stz)-diabetic rats and some underlying mechanisms were investigated.    materials and methods: male diabetic rats receive...

due to the range of its constituents, colostrum has been considered as a supplement for various diverse purposes. this study was conducted to examine the effect of supplementary bovine colostrum on serum malondialdehyde (mda), antioxidant activity (aoa) and glucose in a diabetic rodent model. sixty male wistar rats were divided into 10 groups of six rats each for 40 days as follows: non-diabeti...

background and objectives this study was undertaken to evaluate the effect of the cultivated satureja khuzestanica essential oil (skeo) on activity and gene expression of hepatic gk in normal and diabetic rats.   methods biochemical parameters such as glucose, insulin, and hba1c plasma levels and oral glucose tolerance test were all analyzed. the cultivated skeo was orally administered at diffe...

background and objective: based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid b on lessening of learning and memory deficits in streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats were allocated into control, salvialonic acid b-trea...

objective: this study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. methods: wistar rats were divided into the following six groups:  control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (ss)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). curcumin was ad...

objective(s):hyperglycemia mediated oxidative stress plays a key role in the pathogenesis of diabetic complications like nephropathy. in the present study, we evaluated the effect of ethanolic extract of ensete superbum seeds (esse) on renal dysfunction and oxidative stress in streptozotocin-induced diabetic rats. materials and methods:glucose, hba1c, total protein, albumin, renal function mark...