Dihydrotestosterone (DHT) exerts both functional and signaling effects extending beyond the effects of testosterone in rodent skeletal muscle. As a primer for investigating the role of DHT in human skeletal muscle function, this study aimed to determine whether circulating DHT is acutely elevated in men following a bout of repeat sprint exercise and to establish the importance of training statu...

Intratumoural dihydrotestosterone (DHT) synthesis could be an explanation for castration resistance in prostate cancer (PC). By using liquid chromatography-mass spectrometry, we evaluated the intratumoral DHT synthesis from 5α-androstane-3β,17β-diol (3β-diol), which is inactive androgen metabolized from DHT. 3β-diol had biochemical potential to be converted to DHT via three metabolic pathways a...

Studying deployed Distributed Hash Tables (DHTs) entails monitoring DHT traffic. Commonly, DHT traffic is measured by instrumenting ordinary peers to passively record traffic. In this approach, using a small number of peers leads to a limited (and potentially biased) view of traffic. Alternatively, inserting a large number of peers may disrupt the natural traffic patterns of the DHT and lead to...

Although a distributed index on a distributed hash table (DHT) enables efficient document query processing in Peer-to-Peer information retrieval (P2P IR), the index costs a lot to construct and it tends to be an unfair management because of the unbalanced term frequency distribution. We devised a new distributed index, named Huffman-DHT, for P2P IR. The new index uses an algorithm similar to Hu...

We identified human UDP-glucuronosyltransferase (UGT) isoforms responsible for producing dihydrotestosterone (DHT) diglucuronide, a novel glucuronide in which the second glucuronosyl moiety is attached at the C2' position of the first glucuronosyl moiety, leading to diglucuronosyl conjugation of a single hydroxyl group of DHT at the C17 position. Incubation of the DHT monoglucuronide with 12 cD...

Testosterone, acting through its androgenic metabolite 5alpha-dihydrotestosterone (DHT), can increase dendritic spine density in the CA1 region of the male rat hippocampus. The mechanisms mediating this increase in spines are presently unknown. In female rats, estrogen (E) has been shown to increase spine density, which is in part mediated by increases in N-methyl-d-aspartate (NMDA) receptors i...

Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional activity of androgen receptor (AR) and/or signal transducer and activator of transcription-3 (STAT3) contributes to the proliferation of prostate cancer cells. In the pr...

Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, by acting at the estrogen receptor. DHT as a non-aromatizable androgen could be...

Ödeme sistemlerinde gittikçe yaygınlaşan Internet üzerinden (online/mobil) ve temassız ödemeler, ödeme kullanıcı deneyiminin bu sistemlerin dostu olmasının önemini göstermektedir. Akıllı saat gibi giyilebilir nesneler nesnelerin internetinin (NesNet) sunabileceği dijital ödemeleri devrimleştirmesi beklenmektedir. Bununla birlikte, NesNet’in güvenlik açıkları olduğu bilinmektedir. Bunun en öneml...