We consider the mean delay optimization in the M/G/1 queue for jobs with a service time distribution that has a tail with decreasing hazard rate (DHR). If the DHR property is valid for the whole distribution, then it is known that the Foreground-Background (FB) discipline, which gives priority to the job with least amount of attained service, is optimal among nonanticipating scheduling discipli...

Chronic granulomatous disease (CGD) is a rare genetic disease, which is caused by defects in the NADPH oxidase complex (gp91(phox), p22(phox), p40(phox), p47(phox), and p67(phox)) of phagocytes. This defect results in impaired production of superoxide anions and other reactive oxygen species (ROS), which are necessary for killing bacterial and fungal microorganisms and leads to recurrent, life-...

Some members of nuclear hormone receptors, such as the thyroid hormone receptor (TR), silence gene expression in the absence of the hormone. Corepressors, which bind to the receptor's silencing domain, are involved in this repression. Hormone binding leads to dissociation of corepressors and binding of coactivators, which in turn mediate gene activation. Here, we describe the characteristics of...

In many applications, the system needs to selectively present a small subset of answers to users. The set of all possible answers can be seen as an elevation surface over a domain, where the elevation measures the quality of each answer, and the dimensions of the domain correspond to attributes of the answers with which similarity between answers can be measured. This paper considers the proble...

The Dock180 family of atypical Rho family guanine nucleotide exchange factors (Rho-GEFs) regulate a variety of processes involving cellular or subcellular polarization, including cell migration and phagocytosis. Each contains a Dock homology region-1 (DHR-1) domain that is required to localize its GEF activity to a specific membrane compartment where levels of phosphatidylinositol (3,4,5)-trisp...

Atypical Rho-guanine nucleotide exchange factors (Rho-GEFs) that contain Dock homology regions (DHR-1 and DHR-2) are expressed in a variety of tissues; however, their functions and mechanisms of action remain unclear. We identify key conserved amino acids in the DHR-2 domain that are critical for the catalytic activity of Dock-GEFs (Dock1-4). We further demonstrate that Dock-GEFs directly assoc...

The superselection structure of so(N) WZW models is investigated from the point of view of algebraic quantum field theory. At level 1 it turns out that the observable algebras of the WZW theory can be constructed in terms of even CAR algebras. This fact allows to give a formulation of these models close to the DHR framework. Localized endomorphisms are constructed explicitly in terms of Bogoliu...

Betalactam (BL) antibiotics are the most common cause of drug-induced hypersensitivity reactions (DHR). We present 2 clinical cases patients with suspected immediate BL DHR who underwent drug allergy workup according to standardized diagnostic procedures, including skin tests (STs: prick, prick test, and intradermal [IDTs]) provocation (DPTs).1 ST results became positive after first DPT dose. T...

The performance of cold bitumen emulsion (CBE) mixtures is strongly linked to an optimised design the binder blends and mastics. Types dosages bitumen, mineral additions workability must be characterised optimised. This study aims at providing approach for fundamental characterisation CBE materials using rotational viscometry. Firstly, a procedure measuring viscosity slurries Brookfield viscome...

The characteristics of transmitted acoustic field have important significance to the leakage detection and metasurface technology. When additional leak holes are present, conventional single neck Helmholtz resonator will naturally become one with multiple necks. Based on such a background, in this paper, effects leakages transmission properties Duct Resonator (DHR) device is investigated both a...