Although hypoalbuminaemia after injury may result from increased vascular permeability, dilution secondary to crystalloid infusions may contribute significantly. In this double-blind crossover study, the effects of bolus infusions of crystalloids on serum albumin, haematocrit, serum and urinary biochemistry and bioelectrical impedance analysis were measured in healthy subjects. Ten male volunte...

The beneficial effects of total parenteral nutrition (TPN) in improving the nutritional status of malnourished patients during hospital stays have been well established. However, recent randomized trials and meta-analyses have reported an increased rate of TPN-associated complications and mortality in critically ill patients. The increased risk of complications during TPN therapy has been linke...

Many therapeutic monoclonal antibodies (mAbs) are clinically administered through intravenous infusion after mixing with a diluent, e.g., saline, 5% dextrose. Such a clinical setting increases the likelihood of interactions among mAb molecules, diluent, and plasma components, which may adversely affect product safety and efficacy. Avastin® (bevacizumab) and Herceptin® (trastuzumab), but not Rem...

The contents of the stomach and small intestine of normal rabbits, kept on a diet poor in easily convertible carbohydrates, when removed immediately after killing the animal (by clamping the trachea), usually contain a very small but measurable amount of dextrose (reducing substances). A preceding nephrectomy does not increase the amounts of the dextrose in these viscera. An intravenous injecti...

A brief review of the physiological beliefs relative to diabetes is necessary, as it is on those beliefs that the hypothesis is based. It is taught by the majority of physiologists that all working cells require dextrose for the output of energy, which dextrose is taken from the blood. A cell cannot immediately burn off the dextrose received, but incorporates it first as glycogen, in which stat...

BACKGROUND In the Rehabilitation and Aged Care Services Program at Southern Health in Victoria, saline hypodermoclysis is a relatively common method of rehydration. However, there were questions about the safety and effectiveness of subcutaneous infusion of other fluids and, in particular, dextrose solutions. This review aimed to assess the safety and effectiveness of rehydration of elderly pat...

We describe four patients who developed symptomatic hypoglycaemia following treatment of hyperkalaemia with insulin and dextrose. Two patients had a delayed onset of hypoglycaemia, between 5 and 6 hours after treatment despite use of a 'soluble' type of insulin. A review of the literature revealed a variety of insulin and dextrose regimes but no research to assess the metabolic effects of such ...

The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or met...