INTRODUCTION Symptomatic adrenal adenoma usually presents with systemic symptoms. Depending on the function of the adenoma, the patient can present with pheochromocytoma-like symptoms; primary hyperaldosteronism and Cushing syndrome (weight gain, weakness, depression, and bruising). CASE REPORT A 41 year-old lady presented with multiple metatarsal and phalangeal fractures of the both feet wit...

A previously fit and well 5-year-old girl presented to the emergency department with right hip pain and limp following a minor fall from play equipment. X-ray imaging confirmed the presence of a femoral fracture as well as diffuse sclerosis in the sacrum, pelvis, and bilateral proximal femurs (Fig. 1). MRI scan revealed mild stenosis of auditory canals, optic canals, and foramen magnum with no ...

Objectives: To evaluate BMD in lumbar spine of the same subjects under similar conditions both by QCT and DEXA scanners on the same day and to compare their findings in evaluating these subjects as osteoporotic, osteopenic or normal. Materials and Methods: In this cross sectional study a population of 165 subjects both male and female which included 37 young healthy volunteers, 46 post menopaus...

Appropriate insulin secretion depends on beta-cell mass that is determined by the balance between cell proliferation and death. IGF-1 stimulates proliferation and protects against apoptosis. In contrast, glucocorticoids promote cell death. In this study we examined molecular interactions of the glucocorticoid dexamethasone (dexa) with IGF-1 signalling pathways in insulin secreting INS-1 cells. ...

Methods Prepubertal children aged 3–10 years, (born at full term and not SGA) were recruited and grouped by birth order. All children had height, weight, body composition by DEXA scan and fasting serum IGF-1, IGF-2, IGFBP3, lipids, leptin, adiponectin, glucose and insulin levels recorded. Children’s heights and BMI were expressed as an SDS, and corrected for mean parental height and BMI SDS. A ...

Abstract Background Sarcopenia, characterised by a loss of muscle strength, quantity/quality, and physical performance, is associated with increased mortality poor clinical outcomes in patients liver cirrhosis. The use the currently accepted methods for estimating mass, such as computed tomography, dual-energy X-ray absorptiometry, bioelectrical impedance analysis, routine practice restricted b...

BACKGROUND Skinfold thickness (SFT) and bioelectrical impedance (BIA) are readily available and commonly used techniques in patient monitoring for body composition analysis (BCA) in clinical practise. Another one, dual-energy X-ray absorptiometry (DEXA) method became popular in body composition analysis (BCA) in recent years. Its results have been reported to be quite accurate and precise, in c...

Dual-energy X-ray absorptiometry (DEXA) is reported to be inferior to computed tomography (CT) to measure changes in appendicular soft tissue composition. We compared CT- and DEXA-measured thigh muscle and fat mass to evaluate the random and systematic discrepancies between these two methods. Thigh skeletal muscle area (single-slice CT) was suboptimally (r(2) = 0.74, P < 0.0001) related to DEXA...

Glucocorticoids (GCs), which act on stress pathways, are well-established in the co-treatment of different kinds of tumors; however, the underlying mechanisms by which GCs act are not yet well elucidated. As such, this work investigates the role of glucocorticoids, specifically dexamethasone (DEXA), in the processes referred to as DNA damage and DNA damage response (DDR), establishing a new app...

The present study aims to investigate if Cimicifuga racemosa (L.) Nutt extract (CIMI) reduces deleterious effects of dexamethasone (DEXA) in ovaries cultured vitro. Mouse were collected and DMEM+ only or supplemented with 5 ng/mL CIMI, 4 DEXA, both CIMI DEXA. at 37.5°C 5% CO2 for 6 days. Ovarian morphology, follicular ultrastructure, the levels mRNA Bax, Bcl-2, Caspase-3 evaluated. results show...