The two stable isotopes of hydrogen, protium (H) and deuterium (H) differ in their physicochemical nature. Deuterium-depleted water (DDW) significantly inhibited the growth rate of different tumor cell lines in culture media and xenotransplanted MDA-MB-231, MCF-7 human breast adenocarcinomas and PC-3 human prostate tumors in vivo. The apoptosis-triggering effect of DDW was demonstrated both in ...

Although advances in cancer therapies continue to develop, the shortness of the survival of lung cancer patients is still disappointing. Therefore, finding new adjuvant strategies is within the focus of cancer cure. Based on observations that deuterium depletion inhibits the growth of cancer cell lines and suppresses certain proto-oncogenes, we have conducted a clinical study in 129 patients wi...

This paper describes a method of determining protein synthesis and turnover using in vivo labeling of protein with deuterated water and analysis of matrix-assisted laser desorption time-of-flight mass spectrometer (MALDI-TOF) spectrum. Protein synthesis is calculated using mass isotopomer distribution analysis instead of precursor to product amino acid enrichment ratio. During protein synthesis...

Salinity increase in groundwater was investigated the area between Al-Zubair and Safwan, close to Khor Channel of southern Iraq. Thirty-nine samples from shallow aquifer one sample were analyzed. The mean total dissolved solids are 7556 mg/L. ?2H ?18O plot two groups below global meteoric water line. Group A indicates evaporation effect irrigation return-flow, while group B is characterized by ...

Water movement between cells in a plant body is the basic phenomenon of plant solute transport; however, it has not been well documented due to limitations in observational techniques. This paper reports a visualization technique to observe water movement among plant cells in different tissues using a time of flight-secondary ion mass spectrometry (Tof-SIMS) cryo-system. The specific purpose of...

We have developed a tunable source of Mie scale microdroplet aerosols that can be used for the generation of energetic ions. To demonstrate this potential, a terawatt Ti:Al2O3 laser focused to 2 x 10(19) W/cm2 was used to irradiate heavy water (D2O) aerosols composed of micron-scale droplets. Energetic deuterium ions, which were generated in the laser-droplet interaction, produced deuterium-deu...

The Last Interglacial warm period, the Eemian (ca. 130–116 thousand years ago), serves as a reference for projected future climate in warmer world. However, there is limited understanding of seasonal characteristics interglacial dynamics, especially high latitude regions. In this study, we aim to provide new insights into trends temperature and moisture source location, linked shifts atmospheri...