Rheumatoid arthritis is an autoimmune disease characterized by synovial hyperplasia and progressive joint destruction. As reported previously, recombinant human endostatin (rhEndostatin) is associated with inhibition of joint bone destruction present in rat adjuvant-induced arthritis; however, the effect of rhEndostatin on bone destruction is not known. This study was designed to assess the inh...

Wnt signaling plays key roles in development and disease. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling. Its best-characterized role is as part of the destruction complex, targeting the Wnt effector β-catenin (βcat) for phosphorylation and ultimate destruction, but several studies suggested APC also may act in the nucleus at promoters ...

rheumatoid arthritis (ra) is a chronic autoimmune disease, which can lead to joint destruction and disability. pannus formation due to chronic synovitis is the hallmark of ra. oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. silymarin, an antioxidant extract from silybum marianum, has been tra...

Within the framework of concept complexity, a three-stage model Auger destruction inorganic and organic polymers, including RNA SARS-CoV-2 virus, was constructed. The possibility selective choice initial K-ionization, as well way realizing giant decrease in threshold dose inactivation/destruction due to combined nonlinearity caused by local deformation (bending chirality) elemental composition ...