A 25-year-old woman presented with a lump in the upper outer quadrant of her right breast. She did not volunteer any other history. On examination, she had a 2 cm 3 cm irregular hard lump that was tethered to the skin (Fig. 1a) efeatures typical of a carcinoma. However, she had mentioned ‘‘ibuprofen’’ when she filled in her basic history sheet (Fig. 1b). This prompted a ‘‘why?’’e and a reply ‘‘...

BACKGROUND Desmoid tumor is a rare soft tissues neoplasia characterized by local invasiveness and by a tendency towards local recurrence although not towards metastasization. DISCUSSION Etiology is not clear. Desmoid tumors originate from the monoclonal proliferation of one mesenchymal cell and develop in the context of fascial, muscular and aponeurotic tissue. They are free of capsule and do...

Intrathoracic desmoid tumours are rare soft-tissue neoplasms arising from fascial or musculo-aponeurotic structures, accounting for less than 0.03% of all neoplasms. Most cases in fact represent intrathoracic extension of chest wall tumours. This case report describes the largest recorded true intrathoracic desmoid tumour without mediastinal or chest wall invasion. The tumour was completely exc...

Breast sarcomas arise from connective tissues of the breast and account for fewer than 1% all malignancies. They can be subclassified as primary sarcomas, which de novo are histologically diverse, secondary a result radiation or lymphedema most commonly angiosarcomas. Two other tissue neoplasms that occur within include phyllodes tumors desmoid tumors, exhibit spectrum behaviors. Malignant biol...

Primary benign gastrointestinal mesenchymal tumours are rare neoplasms [1,2]. The non-exhaustive list includes GIST, leiomyoma, desmoids tumour, inflammatory myofibroblastic tumour, inflammatory fibroid polyp, Schwannoma, lymphoma, mesenchymal polyps and glomus tumour. These tumours frequently show similar and overlapping morphology. However the cell of origin is different in different entities...

PURPOSE To evaluate the tolerance of a low dose chemotherapy regimen for desmoid tumours. PATIENTS AND METHODS Patients with desmoids for whom radical resection was impossible or related to extensive mutilation were treated with chemotherapy. Treatment consisted of intravenous methotrexate at a dose of 50mg and vinblastine at a dose of 10mg weekly, scheduled to be given for a total period of ...

Spectrum of Fibroblastic and Myofibroblastic Tumors When one considers soft tissue tumors in pediatrics, tumors of vascular (29%), neurogenic (15%), and myogenic (striated muscle, 14%) origin occur more often than fibroblastic-myofibroblastic tumors (12%). The spectrum of fibroblastic/myofibroblastic tumors is quite divergent from both clinical and histopathologic viewpoints (Table 1). These tu...