Several previously proposed deep learning methods to design amino acid sequences that autonomously fold into a given protein backbone yielded promising results in computational tests but did not outperform conventional energy function-based wet experiments. Here we present the ABACUS-R method, which uses an encoder–decoder network trained using multitask strategy predict sidechain type of centr...

Different stakeholders in the design of an enterprise information system have their own view on that design. To help produce a coherent design this paper presents a framework that aids in specifying relations and consistency rules between such views. The contribution of our framework is that it provides a collection of basic concepts. These basic concepts aid in relating viewpoints by providing...

DSM-PM2 is a platform for designing, implementing and experimenting multithreaded DSM consistency protocols. It provides a generic toolbox which facilitates protocol design and allows for easy experimentation with alternative protocols for a given consistency model. DSM-PM2 is portable across a wide range of clusters. We illustrate its power with figures obtained for different protocols impleme...

Nowadays, the prevailing methodology used to specify software designs is UML. This language consists of various types of diagrams, each one dedicated to a different design aspect. This variety of views, that overlap with respect to the information depicted in each, can leave the overall system design specification in an inconsistent state. Necessarily, some form of consistency checking must be ...

Replication is widely adopted in modern Internet applications and distributed systems to improve the reliability and performance. Though maintaining the strong consistency among replicas can guarantee the correctness of application behaviors, however, it will affect the application performance at the same time because there is a well-known trade-off between consistency and performance. Many rea...