In view of the suppressive effect of tumor necrosis factor a (TNFa) on lipoprotein lipase (LPL) and of the potential proatherogenic effects of these two macrophage secretory products, we have tested the possibility that LPL could modulate the production of T N F a . Treatment of macrophages with lipoprotein lipase induced tumor necrosis factor a gene expression and protein secretion. Maximal in...

Knowledge is today more than ever the most critical resource of organizations. However, at the same time it is also the least-accessible resource that is difficult to share, imitate, buy, sell, store, or evaluate. Organizations should thus have an explicit strategy for the management of their knowledge resources. In this research the authors pay special attention to a knowledge management (KM) ...

Interest in object-otiented analysis (OOA) and object-oriented design (OOD) has increased over the last several years. Proponents of OOA and OOD have called the shift to these methods “revolutionary” and have cited a number of impressive claims with respect to their use. However, empirical research investigating these claims remains in its infancy. Moreover, an examination of the literature rev...

Virtual organizations and knowledge management have been discussed on a very broad scale in literature. However, a holistic view and methods that support implementation of these concepts are rare. Based on the understanding derived from literature and the experience of many action research-based projects, a method is described that addresses these issues for business networks. This includes the...

The concept of fit is central to organization design. In the organizational literature, fit historically has been portrayed as a static concept. Both organizations and their environments, however, are continually changing, so a valid concept of fit needs to reflect organizational dynamics. In this article, I analyze various theoretical perspectives and studies that relate to organizational fit,...

This study looks at how an information and communication technologies (ICT)-rich environment impacts team conflict and conflict management strategies. A case study research method was used. Three teams, part of a graduate class in instructional design, participated in the study. Data were collected through observations of team meetings, interviews with individual members, plus analysis of elect...

Operationalizing mediated presence: Initial steps toward a measure of the construct This paper reports on an exploratory project to investigate mediated presence, a construct defined as the extent to which participants in a virtual environment perceive other participants in that environment as real, immediate or salient. Development and initial testing of a prompt designed to consistently diffe...

Electronic Data Interchange (EDI) is a technology which has shown significant impact not only at the individual organisation level, but at industry-sector and even at the country-level. As the issues to be addressed at these levels are different, a systemic study of EDI technology transfer incorporating multiple levels is necessary for developing a holistic understanding of the transfer process...

Previous work on group technology choice, such as task-technology fit (Goodhue 1995; Zigurs and Buckland 1998), has typically taken a deterministic perspective, failing to substantively consider the impact of individual differences among team members in terms of experience, knowledge, and/or perceptions of the group’s task and technology choices. We attempt to fill this gap in the literature by...

The objective of this article is to show how the design methodology we experimented allows the creation of both actionable and theoretical knowledge and the reinforcement of both types of knowledge. Especially we intend to demonstrate that the design methodology we built enables to originate a generative dance between theoretical and actionable knowledge, and to solve practical problems in cros...