dermatofibrosarcoma protuberans (dfsp) is very rare tumor of dermis layer of skin with the incidence of only 1 case per million per year. dfsp rarely leads to a metastasis (less than 5% have metastasis), but dfsp can recur locally. we publish a rare case of a recurrent dermatofibrosarcoma protuberans and its management with radical excision and interval skin grafting.

PurPoSe: Recent studies have demonstrated the functional heterogeneity of fibroblasts, particularly in terms of their activities during wound healing. Both location within the dermis and embryonic lineages provide a means by which we may now identify the sub-populations of fibroblasts chiefly responsible for connective tissue deposition during scar formation in the dorsal dermis. However, wheth...

The purpose of this study was to clarify the influence of skin thickness on the in vitro permeabilities of 3 model drugs with different physicochemical properties (nicorandil (NR), isosorbide dinitrate (ISDN) and flurbiprofen (FP)) through Sprague-Dawley rat (rat) or Yucatan micropig (YMP) skin. Intact, dermis-split, stratum corneum-stripped or stratum corneum-stripped and dermis-split rat or Y...

Isolated human dermis has been shown to produce a specific collagenase in vitro. Enzyme activity becomes detectable after two days of culture, reaches a peak on the fourth day, and then begins to decline. Like collagenase obtained from cultures of whole human skin, dermal collagenase is inhibited by human serum and EDTA. The possible sources of this enzyme are discussed. Collagenolytic activity...

The purpose of this investigation was to study the formation and origin of basal lamina and anchoring fibrils in adult human skin. Epidermis and dermis were separated by "cold trypsinization." Viable epidermis and viable, inverted dermis were recombined and grafted to the chorioallantoic membrane of embryonated chicken eggs for varying periods up to 10 days. Basal lamina and anchoring fibrils w...

By laser induced breakdown spectroscopy (LIBS) analysis of epidermal lesion and dermis tissue pellets of hairless mouse, it is shown that Ca intensity in the epidermal lesion is higher than that in dermis, whereas Na and K intensities have an opposite tendency. It is demonstrated that epidermal lesion and normal dermis can be differentiated with high selectivity either by univariate or multivar...

We used a panel of monoclonal antibodies to characterize DCs in the dermis of normal human skin. Staining for the CD11c integrin, which is abundant on many kinds of DCs, revealed cells in the upper dermis. These cells were positive for blood DC antigen-1 (BDCA-1; also known as CD1c), HLA-DR, and CD45, markers that are also expressed by circulating myeloid DCs. A small subset of CD11c+ dermal ce...

BACKGROUND Systemic sclerosis or scleroderma is a rare collagen disease, characterized by insufficient angiogenesis. Few data are available about the morphologic and histochemical peculiarities of the skin in these patients with this condition. The purpose of the present work was to evaluate the histochemical aspects of sclerodermic skin, obtained through biopsy of the typical lesions from the ...

OBJECTIVE To compare the postoperative healing profiles of graft materials used for endoscopic repair of cerebrospinal fluid (CSF) leak. DESIGN Retrospective cohort study with 1 to 21 months of follow-up. SETTING Tertiary referral, academic medical center. PATIENTS Consecutive sample of patients undergoing endoscopic repair of CSF leak from March 2007 through May 2009. INTERVENTION Endo...