نتایج جستجو برای: derived neurotropic factor

تعداد نتایج: 1260901  

2014
Yuling Zhao Matthew J. Haney Richa Gupta John P. Bohnsack Zhijian He Alexander V. Kabanov Elena V. Batrakova Tsuneya Ikezu

The pathobiology of Parkinson's disease (PD) is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) projecting to the striatum. Currently, there are no treatments that can halt or reverse the course of PD; only palliative therapies, such as replacement strategies for missing neurotransmitters, exist. Thus, the successful brain delivery of neurotrophic f...

Journal: :caspian journal of neurological sciences 0
parvin babaei physiology department, faculty of medicine, guilan university of medical sciences, rasht, iran ; [email protected] sanaz vahdati bahram soltani-tehrani

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

Journal: :iranian journal of medical sciences 0
shahla shojaei department of clinical biochemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran mohammad reza panjehshahin department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran; sayed mohammad shafiee department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; zahra khoshdel department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; mohammad borji department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran; ghasem ghasempour department of biochemistry and recombinant protein laboratory, school of medicine, shiraz university of medical sciences, shiraz, iran;

background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده علوم 1392

چ فده قیقحت : هدننک دک یلاوت زا یپک ود یاراد ینایب روتکو تخاس هعلاطم نیا زا فده gdnf نایب یارب یناسنا .تسا نارادناتسپ یلولس هدر رد : قیقحت شور cds نیئتورپ gdnf صخشم یکیتامروفناویب تاعلاطم هلیسو هب یناسنا دیدرگ تفج ود کمک اب . اب هک یرمیارپ رازفا مرن oligo7.4 یحارط دندش رد هناشن دیتپپ ، n و نیئتورپ لانیمرت his-tag رد c نآ لانیمرت شور زا هدافتسا اب .تفرگ رارق t/a cloning روتکو رد هدش دی...

Journal: :iranian red crescent medical journal 0
rasoul eslami faculty of physical education and sport sciences, allameh tabataba’i university, tehran, ir iran reza gharakhanlou physical education department, faculty of humanity and literature, tarbiat modares university, tehran, ir iran abdolreza kazemi neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran; physical education department, faculty of humanity and literature, vali-e-asr university of rafsanjan, rafsanjan, ir iran; neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran and physical education department, faculty of humanity and literature, vali-e-asr university of rafsanjan, rafsanjan, ir iran. tel: +98-9133982706 amir bahador dakhili neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran ghazaleh sorkhkamanzadeh neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, ir iran ayob sheikhy department of statistics, faculty of mathematics and computer, shahid bahonar university of kerman, kerman, ir iran

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

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