Oxidation of the bisenolates of 3-acyltetramic acid to the corresponding 5-hydroxylated compounds using molecular oxygen is reported. The deprotection of the resulting compounds was also achieved.

The use of the ammonia deprotection step to introduce (15)N labels at specific exocyclic amino positions of adenine, cytosine, guanine or 2-aminopurine of oligodeoxynucleotides is described.

We report an organocatalyzed direct enantioselective hydrophosphonylation of N-unsubstituted ketimines that affords N-unprotected α-tetrasubstituted α-aminophosphonates without protection/deprotection steps. The reaction is suitable for isatin-derived and trifluoromethyl ketimines, affording products in high yields with excellent enantioselectivity. Applications the a proposed transition state ...

High activation energy, chemically amplified resist systems exhibit a 4% to 15% volume shrinkage during the post-exposure bake process. Current lithography process simulators do not take this volume shrinkage into account, thus violating the continuity equations used to model the process. This work aims at describing the kinetics of the post-exposure bake process by tracking the volume shrinkag...

Deprotection of phosphate, phosphate, and sulfite esters by silica chloride is described. Silica chloride is a mild, selective, and effective reagent for cleavage of benzyl and t-butyl esters of the above compounds.

Electron paramagnetic resonance (EPR) was used to optimize the solid-phase peptide synthesis of a membrane-bound peptide labeled with TOAC (2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid). The incorporation of this paramagnetic amino acid results in a nitroxide spin label coupled rigidly to the alpha-carbon, providing direct detection of peptide backbone dynamics by EPR. We app...

Strategies for the preparation of polycarbonates, derived from natural polyhydroxy monomeric repeat units, were developed for biosourced polycarbonates based on quinic acid. The design and synthesis of regioselectively tert-butyldimethylsilyloxy (TBS)-protected 1,4- and 1,5-diol monomers of quinic acid were followed by optimization of their copolymerizations with phosgene, generated in situ fro...