BACKGROUND Leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, is used worldwide in premenopausal women with hormone receptor-positive breast cancer. This study was conducted to assess the non-inferiority of the 6-month depot formulation, TAP-144-SR (6M) 22.5 mg to the 3-month depot formulation, TAP-144-SR (3M) 11.25 mg in postoperative, premenopausal patients with hormone rec...

In this paper we present an exact algorithm for the Capacitated LocationRouting Problem (CLRP) based on column and cut generation. The CLRP is formulated as a set-partitioning problem which also inherits all of the known valid inequalities for the flow formulations of the CLRP. We introduce five new families of inequalities that are shown to dominate some of the cuts from the two-index formulat...

This letter concerns optimal power transmission line inspection formulated as a proposed generalization of the traveling salesman problem for multi-route one-depot scenario. The is an vehicle with limited travel budget. Therefore, solution can be composed multiple runs to provide full coverage given lines. Besides, indicates how many vehicles perform in single run. solved by Integer Linear Prog...

To the Editors: The January 1, 2007, issue of Clinical Cancer Research includes a retrospective analysis by Dr. Smith of two previously reported prospective studies of gonadotropinreleasing hormone agonist treatment in men with locally advanced or recurrent nonmetastatic prostate cancer (1). It was concluded that despite lower pretreatment serum testosterone levels, obese men have higher total ...

The present work aims to support tactical and operational planning decisions of reverse logistics systems while considering economic, environmental and social objectives. In the literature, when addressing such systems economic aspects have been often used, while environmental concerns have emerged only recently. The social component is the one less studied and rarely the combination of the thr...

The Multiple Depot Ring-Star Problem (MDRSP) is an important combinatorial optimization problem that arises in the context of optical fiber network design, and in applications pertaining to collecting data using stationary sensing devices and autonomous vehicles. Given the locations of a set of customers and a set of depots, the goal is to (i) find a set of simple cycles such that each cycle (r...

We introduce the Synchronized Multi-Assignment Orienteering Problem (SMOP), a vehicle routing problem that requires jointly selecting set of jobs while synchronizing assignment and transportation agents to roles form ad-hoc teams at different job locations. Agents must be assigned only for which they are qualified. Each certain number in each role within time window contributes reward score if ...