oxymatrine, a potent monosomic alkaloid extracted from chinese herb sophora japonica (sophora flavescens ait.). possesses anti-inflammatory activittyes.  this study was designed to investigate the effects of oxymatrine on nuclear factor–kappa b (nf-κb) and mitogen-activated protein kinase (mapk)-dependent inflammatory responses in lipopolysaccharide (lps)-activated microglia. in this paper, bv2...

ownload lin-dependent kinases (CDK) are key positive regulators of cell cycle progression and attractive targets ology. SCH 727965 inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, nmol/L, respectively. SCH 727965 was selected as a clinical candidate using a functional screen in vivo tegrated both efficacy and safety parameters. Comparedwith flavopiridol, SCH 72...

Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...