We consider estimation of the joint distribution of multivariate survival times ~ T = (T1, . . . , Tk), which are subject to right censoring by a common censoring variable C. Two estimators are proposed: an initial inverse-probability-ofcensoring weighted (IPCW) estimator, and a 1-step estimator. Both estimators incorporate information on available time-independent and time-dependent prognostic...

A measure of the predictive capability of a proportional hazards regression is derived. The measure is based on the residuals appropriate to proportional hazards regression. A population version is presented and can be seen not to depend on the censoring mechanism under the provision that any such censoring be independent or conditionally independent of the failure mechanism given the covariate...

Semiparametric maximum likelihood estimators have recently been proposed for a class of two-phase, outcome dependent sampling models; e.g. Breslow and Holubkov (1997), Scott and Wild (1998), and Lawless, Wild, and Kalb eisch (1999). The estimators studied by these authors are predicated on the estimates of the underlying covariate distribution being concentrated on the observed covariate values...

Regression analysis is the method of choice for the production of covariate-dependent reference limits. There are currently no recommendations on what sample size should be used when regression-based reference limits and confidence intervals are calculated. In this study we used Monte Carlo simulation to study a reference sample group of 374 age-dependent hemoglobin values. From this sample, 50...