objective(s): there are few reports have demonstrated the effect of a change-in-light experience on the structure and function of hippocampus. a change-in-light experience also affects the circadian pattern of melatonin secretion. this study aimed to investigate developmental effect of exogenous melatonin on synaptic plasticity of hippocampus of light deprived rats. materials and methods: the e...

the present work was aimed to design and develop self-nanoemulsifying drug delivery systems (snedds) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having ph dependant solubility. the solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

Background Polymerase chain reaction (PCR) is emerging as a new diagnostic tool for tubercular infections. Studies indicate variable results in relation to its efficacy making it as an investigation which is operator dependant. It still remains a dilemma to choose between PCR and culture as the most dependant and reliable diagnostic test. The purpose of our study was to determine the efficacy o...