W ithin this thesis, the Computational Fluid Dynamics method Smoothed Particle Hydrodynamics (SPH) is applied to simulate bubble induced mixing in wastewater treatment plants for the first time. To do so, a new SPH multiphase algorithm is presented that is especially designed to be very cheap in terms of computational costs and solves the problem that air bubbles are only stable for a short tim...

Spectrin is the backbone of the erythroid cytoskeleton; sph/sph mice have severe hereditary spherocytosis (HS) because of a mutation in the murine erythroid alpha-spectrin gene. sph/sph mice have a high incidence of thrombosis and infarction in multiple tissues, suggesting significant vascular dysfunction. In the current study, we provide evidence for both pulmonary and systemic vascular dysfun...

We constructed a minilibrary using a solution-phase synthesis through coupling of three core amino compounds (5'-amino-5'-deoxy uridine, 5'-amino-2',5'-di-deoxy arabinosyl uridine, and butan-1-amine) with 30 carboxylic acids via amide bond formation. The simplified structural core compound butan-1-amine was selectively coupled with 9 carboxylic acids as control. 3-(4,5-Dimethyl-2-thiazolyl)-2,5...

BACKGROUND Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree partic...

Tetramers of αand β-spectrin heterodimers, linked via intermediary proteins to transmembrane proteins, stabilize the red blood cell cytoskeleton. Deficiencies of either αor β-spectrin can result in severe hereditary spherocytosis or elliptocytosis (HS/HE) in mice and humans. Four mouse mutations, sph, sph, sph, and sph, affect the erythroid αspectrin gene, Spna1, on Chromosome 1 and cause sever...

It has been shown through recent investigations in biomechanics, that marrow can play a critical role upon the cancellous bone behavior [1]. Besides its direct influence on the transport properties including pressure drop, shear dissipated energy and tortuosity of the bone geometry, the marrow is also responsible in transmitting and regulating the inter-lamellas pressure [2], due to external lo...

8 9 Plant based dried food products are popular commodities in global market where much research is focused to improve 10 the products and processing techniques. In this regard, numerical modelling is highly applicable and in this work, a 11 coupled meshfree particle-based two-dimensional (2-D) model was developed to simulate micro-scale deformations of 12 plant cells during drying. Smoothed Pa...

The penetration of projectiles into targets has a broad background in engineering. In this work, numerical simulations the projectile-target problem are conducted using Finite Element Method (FEM), Smoothed Particle Hydrodynamics (SPH) and Element–Smoothed Adaptive Coupling (FE-SPH ACM) based on LS-DYNA software package. First, experiments aluminum ceramic simulated. experimental simulation res...

In this paper, we present a novel method to couple Smoothed Particle Hydrodynamics (SPH) and nonlinear FEM to animate the interaction of fluids and deformable solids in real time. To accurately model the coupling, we generate proxy particles over the boundary of deformable solids to facilitate the interaction with fluid particles, and develop an efficient method to distribute the coupling force...