Treatment of metastatic castration-resistant prostate cancer is complex and we are facing more questions with major practical impact with the available effective drugs. Treatment optimization requires that all clinical partners work together. Survival is linked to the number of regimen used. The androgen pathway is key, while chemotherapy is the other major tool.

Logic is not just about single-agent notions like reasoning, or zero-agent notions like truth, but also about communication between two or more people. What we tell and ask each other can be just as logical as what we infer in Olympic solitude. We show how communication and other interactive phenomena can be studied systematically by merging epistemic and dynamic logic, leading to new types of ...

Complex social behavior builds on the mutual judgment of individuals as cooperation partners and competitors [1]. Play can be used for assessing the others' dispositions in humans and nonhuman mammals [2], whereas little is known about birds. Recently, food-caching corvids have been found to rival primates in their ability to judge the behaviors and intentions of others in competition for hidde...

15-day increase in hospital length of stay (LOS), a financial impact of $4 billion to $16 billion annually, and a 19% increase in 6-month mortality. Delirium is common across all patient settings; the prevalence, however, varies according to acuity of illness. Delirium develops in general medicine patients at rates ranging from 11% to 42%. The highest prevalence of delirium, as high as 87%, occ...

This study demonstrated an e-learning system, MyEVA, based on a mixed-modality vocabulary strategy in assisting learners of English as a second language (L2 learners) to improve their vocabulary. To explore the learning effectiveness of MyEVA, the study compared four vocabulary-learning techniques, MyEVA in preference mode, MyEVA in basic mode, an Internet dictionary, and a traditional paper-ba...

Male sex workers (MSWs) and sex trades are not new in Bangladesh. Current HIV interventions for MSWs need to be expanded in the major cities, but the number of MSWs needs to be scientifically estimated. Although two-sample capture-recapture surveys are suitable for closed populations, this method was here applied to indirectly estimate the number of mobile MSWs in a conservative social setting,...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

objective: this study focused on the factors affecting the institutional delivery and delivery assisted by health professionals in urban slums. materials and methods: a semi-structured questionnaire was developed to collect information from women aged 15-49 who had at least one birth. totally 540 eligible women were interviewed. results: the results showed that around 20% of women delivered at ...