Abstract Japanese has a deletion operation, called argument ellipsis, that targets arguments (Oku in A theory of selection and reconstruction the minimalist program, 1998). The operation does not apply to adjuncts, thus, adjuncts are unelidable. Funakoshi (J East Asian Linguist 25(2):113–42, 2016), following footsteps Otani Whitman (Linguist Inquiry 22:345–58, 1991), argues can be elided when V...

A well-known problem in data science and machine learning is linear regression, which recently extended to dynamic graphs. Existing exact algorithms for updating the solution of graph regression require at least a time (in terms n: size graph). However, this complexity might be intractable practice. In current paper, we utilize subsampled randomized Hadamard transformand CountSketchto propose f...

spinal muscular atrophy (sma) is a common autosomal recessive neuromuscular disorder caused by the loss of α-motor neurons in the spinal cord. the survival motor neuron (smn) protein is encoded by 2 genes, smn1 and smn2. the most frequent mutation is the biallelic deletion of exon 7 of the smn1 gene. smn2 cannot compensate for the loss of smn1, due to the exclusion of exon 7. carrier frequency ...

Abstract Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. cases imported Australia (n = 210, collected 2010–2018) for their status. detected gene deletions patients from 12 25 countries. found >10% pfhrp2-deletion levels those Nigeria (13.3%, n 30), Sudan (11.2%, 39), and So...

Next-generation sequencing (NGS) from SARS-CoV-2-positive swabs collected during the last months of 2022 revealed a large deletion spanning ORF7b and ORF8 (426 nt) in six patients infected with BA.5.1 Omicron variant. This extensive genome loss removed part these two genes, maintaining frame first 22 aminoacids three ORF8. Interestingly, deleted region was flanked by small repeats, which were l...

Telomerase and systems controlling their activity have been of great attention. There are controversies regarding the role of the alternative splicing forms of the human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase. Therefore, the correlation between telomerase enzyme activity, the abundance of alternatively spliced variants of hTERT and doubling time of a seri...