We hypothesized that diabetic sensory neuropathy is associated with activation of apoptosis and concomitant mitochondrial dysfunction. Studies were performed in excised intact and acutely dissociated dorsal root ganglion (DRG) neurons from control and streptozotocin-induced diabetic rats with decreased peripheral nerve conduction velocities (NCV). Apoptosis was increased in acutely dissociated ...

Two cases of Guillain-Barré syndrome occurring in association with chronic pulmonary tuberculosis are reported. A cell-mediated, delayed hypersensitivity reaction to, or invasion of the nerve roots by tubercle bacilli would seem to be the likely explanation of the neuropathy.

A 50 year old man with Addison's disease suffered two episodes of hyperkalaemic paralysis, with delayed muscular relaxation and persistent motor neuron discharges at rest resembling the Isaacs-Mertens syndrome. Sural nerve biopsy shows a demyelinating neuropathy. The symptoms ceased after corticosteroid therapy.

A 46 year old Asian male with previously treated lepromatous leprosy developed a stepwise multifocal sensory disturbance 25 years later. Neurophysiology demonstrated marked deterioration from previous studies. Sural nerve biopsy disclosed a vasculitic process superimposed on inactive lepromatous leprosy. Immunocytochemical stains for mycobacterial antigen showed deposits within nerve and vessel...

Caro editor, Inicialmente, parabenizo os colegas do Ceará pelo interessante artigo 1, Neuropatia Silenciosa em Portadores de Hanseníase na Cidade de Fortaleza, Ceará, Brasil, visto a importância social desta patologia no Brasil, sendo negligenciada em locais de baixa prevalência (1,4/100.000 habitantes) como o Rio Grande do Sul 2. Esse fato é preocupante, pois as queixas de alteração de sensibi...

Protective effects of prednisolone as a synthetic adrenal cortical hormone and complex of vitamin B(1), B(2), B(6) and B (12) on organophosphorus compound-induced delayed neurotoxicity (OPIDN) caused by leptophos and tri-o-cresyl phosphate (TOCP) as organophosphates (OPs) were examined. Nine groups of hens (six for each) were used. Eight groups received intravenous injection of 30 mg/kg of lept...

background: the use of organophosphates (ops) in developing countries is rising in large quantities and non-secure methods. this problem not only causes acute poisoning but also may lead to chronic diseases such as polyneuropathy. in iran, 60% of pesticides are organophosphate compounds that may lead to delayed polyneuropathy. objectives: the purpose of the current study was to evaluate delayed...

nal intensity on T1-weighted images and variable signal ranging from hypo to hyperintensity on T2-weighted images. The fat content is seen strongly hyperintense on T1-weighted imaging while the other contents appear hypointense. On T2weighted sequences, the fat component demonstrates hypointensity similar to subcutaneous fat. A thin rim of calcification is frequently present. Additionally, curv...