Lynch syndrome is one of the most common cancer susceptibility syndromes. Individuals with Lynch syndrome have a 50%-70% lifetime risk of colorectal cancer, 40%-60% risk of endometrial cancer, and increased risks of several other malignancies. It is caused by germline mutations in the DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2. In a subset of patients, Lynch syndrome is caused by 3' end...

It is sometimes difficult to diagnose Lynch syndrome by the simple but strict clinical criteria, or even by the definitive genetic testing for causative germline mutation of mismatch repair genes. Thus, some practical and efficient screening strategy to select highly possible Lynch syndrome patients is exceedingly desirable. We performed a comprehensive study to evaluate the methylation status ...

1311 Efficacy of a Telehealth Intervention on Colonoscopy Uptake When Cost Is a Barrier: The Family CARE Cluster Randomized Controlled Trial Laurie E. Steffen, Kenneth M. Boucher, Barbara H. Damron, Lisa M. Pappas, Scott T. Walters, Kristina G. Flores, Watcharaporn Boonyasiriwat, Sally W. Vernon, Antoinette M. Stroup, Marc D. Schwartz, Sandra L. Edwards, Wendy K. Kohlmann, Jan T. Lowery, Charle...

Domenico Corrado, MD, PhD; Hugh Calkins, MD; Mark S. Link, MD; Loira Leoni, MD, PhD; Stefano Favale, MD; Michela Bevilacqua, MD; Cristina Basso, MD, PhD; Deirdre Ward, MD; Giuseppe Boriani, MD; Renato Ricci, MD; Jonathan P. Piccini, MD; Darshan Dalal, MD, MPH; Massimo Santini, MD; Gianfranco Buja, MD; Sabino Iliceto, MD; N.A. Mark Estes III, MD; Thomas Wichter, MD; William J. McKenna, MD; Gaeta...

The “rescue” of Private Jessica Lynch was one of the most extensively covered events of the 2003 US-led war on Iraq. In the 14 days after her rescue, Lynch drew 919 references in major newspapers. In contrast, General Tommy Franks, who ran the war, got 639 references, and Dick Cheney got 549 (Christopher Hanson 2003). The coverage of the Lynch story continued well into the year and far outstrip...

Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for as much as 3% of all colon and endometrial cancers. The identification and management of individuals with Lynch syndrome have evolved over the past 20 years, yet the syndrome remains vastly underdiagnosed. It is important for clinicians to recognize individuals and families who are at risk in order to be able t...

High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer. Many of the characteristics associated with Lynch Synd...

Background Recent genome-wide association studies (GWAS) have identified several common low-risk variants for colorectal cancer. Although some of the GWAS were enriched for young onset and family history positive colorectal cancer cases, it is not clear if these variants modify colorectal cancer risk for people with Lynch syndrome. In a case-unaffected sibling analysis of population and clinic ...

Kawasan adalah sebuah tempat yang mempunyai bagian-bagian penting berperan menampung kegiatan manusia berdasarkan kebutuhannya masing-masing. Semakin baiknya penataan pada kawasan, tidak terlepas dari peranan elemen pembentuk citra kota tersebut. Elemen menurut teori Kevin Lynch terdiri atas path, edge, district, node, dan landmark. Kota Depok berada di Provinsi Jawa Barat, Indonesia, berdekata...

Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes. Although CRC usually occurs after the fourth decade in patients with Lynch syndrome harboring a heterozygous MMR gene mutation, it can occur in children with Lynch syndrome w...